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Table 3 Cox univariate analyses of metastasis-free survival.

From: Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers

Region of amplification

Population

5-year M FS [95% CI]

Hazard ratio [95% CI]

p-value

 

W hole

N +

N -

With amplification

Without amplification

  

8p12

+

  

68.75 [56.73–83.3]

82.4 [76.6–88.7]

2.25 [1.28–3.93]

0.0046

8p12

 

+

 

63.2 [46.6–85.6]

72.6 [63–83.67]

1.87 [0.95–3.71]

0.071

8p12

  

+

73.77 [57.59–94.49]

91.33 [85.37–97.70]

2.98 [1.1–8.06]

0.031

8q24

+

  

78.6 [59.8–100]

82.61 [77.63–87.92]

0.825 [0.25–2.75]

0.75

8q24

 

+

 

75 [50.3–100]

74.53 [66.32–83.75]

0.728 [0.17–3.04]

0.66

8q24

  

+

83.3 [58.3–100]

89.55 [84.09–95.36]

0.825 [0.09–7.66]

0.87

11q13

+

  

75.93 [65.28–88.31]

83.95 [79.18–89]

1.46 [0.8–2.67]

0.22

11q13

 

+

 

75.72 [61.54–93.17]

74 [65.7–83.4]

0.962 [0.44–2.1]

0.92

11q13

  

+

76.02 [60.88–94.92]

91.72 [86.91–96.80]

2.46 [0.93–6.48]

0.069

12p13

+

  

91.67 [77.29–100]

82.23 [77.85–86.85]

0.427 [0.06–3.08]

0.4

12p13

 

+

 

100 [100-100]

72.14 [64.84–80.26]

*

1

12p13

  

+

83.3 [58.3–100]

91.28 [86.85–95.94]

2.46 [0.32–18.75]

0.39

17q12

+

  

64.7 [47.5–88.2]

83.92 [79.28–88.83]

2.09 [1.02–4.26]

0.044

17q12

 

+

 

68.2 [48.6–95.7]

75.37 [67.54–84.10]

1.24 [0.52–2.95]

0.63

17q12

  

+

55.6 [27.4–100]

91.25 [86.44–96.33]

4.2 [1.18–14.95]

0.027

20q13Z

+

  

85.4 [71.27–100]

79.43 [73.82–85.47]

0.57 [0.18–1.83]

0.35

20q13Z

 

+

 

90.91 [75.41–100]

63.98 [54.65–74.89]

0.186 [0.03–1.35]

0.097

20q13Z

  

+

79.5 [57.7–100]

93.05 [88.18–98.19]

2.58 [0.55–12.15]

0.23

20q13Co

+

  

90.43 [78.63–100]

79.80 [74.71–85.24]

0.364 [0.09–1.51]

0.16

20q13Co

 

+

 

87.84 [73.37–100]

66.80 [58.20–76.66]

0.276 [0.07–1.15]

0.076

20q13Co

  

+

100 [100-100]

90.40 [85.35–95.75]

*

1

  1. *No event in the amplified group