Figure 5

Panel A: Alternative splicing of ATR Δ33 exon. Schematic representation of the design used to assess the existence of mRNA splice transcript encompassing exons 33 and 34 in immortalized cell lines of individuals affected with breast cancer. The putative truncated ATR protein of 1889 amino acids lacks the functional domains identified in the wild type ATR protein. Panel B: Alternative splicing of ATR insΔInt41 exon. Schematic representation of the design used to assess the existence of mRNA splice transcript encompassing exons 41 and 42 in immortalized cell lines of individuals affected with breast cancer. The putative truncated ATR protein of 2350 amino acids lacks a part of the kinase domains identified in the wild type ATR protein.