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Table 2 Previous treatments in patients achieving clinical benefit

From: Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer

Best response

Progression at study entry

Previous lines of chemotherapy for metastatic disease

Previous Trastuzumab-lines for metastatic disease

SD ≥ 24 weeks

NO

3

3

SD ≥ 24 weeks

NO

4

1

SD ≥ 24 weeks

YES*

4

1

SD ≥ 24 weeks

NO

3

1

SD ≥ 24 weeks

YES

4

1

SD ≥ 24 weeks

YES**

4

2

PR

YES*

3

2

PR

NO

8

3

PR

NO

2

1

PR

YES*

5

2

  1. * Progression at study entry to Trastuzumab-containing regimen
  2. ** Progression to the last Trastuzumab-containing regimen