Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8

Table 4 Genes of interest mapped to 8q and 2p.

Gene	Cytoband	Affymetrix probe set	Overall Survival (p value¹)	Progression- Free Survival (p value¹)	Mean Fold Change by Microarray (ratio of tumors with CNA: tumors without CNA)² (p value)
Ribosomal protein S20 ( *RPS20* )	8q12	HG1800-HT1823_at	0.0005*	0.0213*	1.58 (0.025)**
Ribosomal protein L30 ( *RPL30* )	8q22	HG2873-HT3017_at	0.014*	0.0018*	1.78 (0.0162)**
Euskaryotic translation elongation factor 1 delta ( *EEF1D* )	8q24.3	Z21507_at	0.014*	0.0085*	1.71 (0.0089)**
*MYC*	8q24.12-q24.13	L00058_at and HG3523-HT4899_s_at	0.218–0.378	0.223–0.506	1.35 and 2.99 (0.38 and 0.26)
*MYCN*	2p24.1	M13241_at	0.403	0.661	1.56 (0.31)

¹ Kaplan-Meier analysis of 64 patients stratified by microarray-based gene expression levels using Affymetrix HuGeneFL microarrays. Significance determined by log-rank test.
² Ratio calculated from expression levels in 27 patient samples with and without the specific CNA (8q or 2p gain), using HuGeneFL microarrays. Significance determined by log-rank test.
* Statistically significant differences in overall survival based on microarray expression levels.
** Statistically significant differences in microarray expression levels among tumors analyzed by both CGH and microarray.

ISSN: 1471-2407