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Table 4 Genes of interest mapped to 8q and 2p.

From: Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8

Gene Cytoband Affymetrix probe set Overall Survival (p value1) Progression- Free Survival (p value1) Mean Fold Change by Microarray (ratio of tumors with CNA: tumors without CNA)2 (p value)
Ribosomal protein S20 ( RPS20 ) 8q12 HG1800-HT1823_at 0.0005* 0.0213* 1.58 (0.025)**
Ribosomal protein L30 ( RPL30 ) 8q22 HG2873-HT3017_at 0.014* 0.0018* 1.78 (0.0162)**
Euskaryotic translation elongation factor 1 delta ( EEF1D ) 8q24.3 Z21507_at 0.014* 0.0085* 1.71 (0.0089)**
MYC 8q24.12-q24.13 L00058_at and HG3523-HT4899_s_at 0.218–0.378 0.223–0.506 1.35 and 2.99 (0.38 and 0.26)
MYCN 2p24.1 M13241_at 0.403 0.661 1.56 (0.31)
  1. 1 Kaplan-Meier analysis of 64 patients stratified by microarray-based gene expression levels using Affymetrix HuGeneFL microarrays. Significance determined by log-rank test.
  2. 2 Ratio calculated from expression levels in 27 patient samples with and without the specific CNA (8q or 2p gain), using HuGeneFL microarrays. Significance determined by log-rank test.
  3. * Statistically significant differences in overall survival based on microarray expression levels.
  4. ** Statistically significant differences in microarray expression levels among tumors analyzed by both CGH and microarray.