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Table 2 Association of CpG island hypermethylation and clinico-pathological parameters in cervical cancer.

From: Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

  All subjects DAPK p16 MGMT PTEN Any loci
   + - + - + - + - + -
Cases 127 72 55 32 95 21 106 20 107 92 35
Mean age (yrs) 51.9 52.8 50.7 53.5 51.4 49.8 52.3 52.9 51.7 53.0 48.9
P value(t-test)    0.422   0.484   0.463   0.734   0.152
Stage            
I 61 31 30 19 42 14 47 11 50 41 20
II 46 27 19 11 35 7 39 7 39 36 10
III-IV 20 14 6 2 18 0 20 2 18 15 5
   P value(χ2 test)    0.305   0.162   0.030c   0.688   0.431
Gradea            
G1 40 25 15 13 27 7 33 8 32 31 9
G2–3 84 46 38 18 66 13 71 12 72 60 24
   P value(χ2 test)    0.416   0.183   0.775   0.419   0.475
Histological type            
SCC 98 62 36 24 74 16 82 10 88 74 24
AC 29 10 19 8 21 5 24 10 19 18 11
   P value(χ2 test)    0.006   0.736   0.907   0.002   0.155
Response to radiotherapyb            
Radiosensitive 44 30 14 12 32 8 36 5 39 36 8
Radioresistant 19 9 10 3 16 2 17 3 16 11 8
   P value(χ2 test)    0.118   0.326   0.445   0.628   0.045
  1. aWHO grading is not available for three cases.
  2. bA total of 63 cases received primary radiotherapy and had the data of response to radiotherapy. cComparison was made between stages I+II and stages III+IV.