Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

BMC Cancer

Table 2 Association of CpG island hypermethylation and clinico-pathological parameters in cervical cancer.

	All subjects	DAPK		p16		MGMT		PTEN		Any loci
		+	-	+	-	+	-	+	-	+	-
Cases	127	72	55	32	95	21	106	20	107	92	35
Mean age (yrs)	51.9	52.8	50.7	53.5	51.4	49.8	52.3	52.9	51.7	53.0	48.9
P value(t-test)			0.422		0.484		0.463		0.734		0.152
Stage
I	61	31	30	19	42	14	47	11	50	41	20
II	46	27	19	11	35	7	39	7	39	36	10
III-IV	20	14	6	2	18	0	20	2	18	15	5
P value(χ² test)			0.305		0.162		0.030^c		0.688		0.431
Grade^a
G1	40	25	15	13	27	7	33	8	32	31	9
G2–3	84	46	38	18	66	13	71	12	72	60	24
P value(χ² test)			0.416		0.183		0.775		0.419		0.475
Histological type
SCC	98	62	36	24	74	16	82	10	88	74	24
AC	29	10	19	8	21	5	24	10	19	18	11
P value(χ² test)			0.006		0.736		0.907		0.002		0.155
Response to radiotherapy^b
Radiosensitive	44	30	14	12	32	8	36	5	39	36	8
Radioresistant	19	9	10	3	16	2	17	3	16	11	8
P value(χ² test)			0.118		0.326		0.445		0.628		0.045

^aWHO grading is not available for three cases.
^bA total of 63 cases received primary radiotherapy and had the data of response to radiotherapy. ^cComparison was made between stages I+II and stages III+IV.

ISSN: 1471-2407