HEX nuclear localization in lactating breast. Panel A: non-lactating tissue. Panel B: lactating tissue. Panel C: quantification of the HEX nuclear positivity in non-lactating and lactating breast tissues. HEX nuclear positivity was evaluated by calculating separately nuclear and cytoplasmic reactivity in 1000 cells. Each bar represents the mean value ± standard deviation of nuclear HEX, expressed as percentage of stained cells in the nucleus.