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Table 2 Polyamine levels, enzymatic activities and genes expression in normal and neoplastic colorectal tissues

From: Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer

  Normal Neoplastic p
Putrescine 18.74 ± 3.1 50.87 ± 10.5 0.001
Spermidine 150.1 ± 10.6 302.2 ± 27.8 <0.0001
Spermine 387.3 ± 27.98 538.0 ± 41.7 0.003
Total polyamines 556.2 ± 39.9 891.0 ± 70.7 0.0002
ODC 21.2 ± 3.5 274.2 ± 70.9 <0.0001
SSAT 27.4 ± 3.8 40.4 ± 5.0 0.030
ODC mRNA 12.5 ± 2.0 20.7 ± 5.0 0.020
SSAT mRNA 2.7 ± 0.3 13.6 ± 1.5 <0.0001
PPARγ mRNA 0.3 ± 0.05 2.8 ± 0.5 <0.0001
  1. Polyamines are reported as nmol/g wet tissue. ODC activity is expressed as pmol 14CO2/h/mg of protein. SSAT activity is expressed as pmol N1-[14C] acetylspermidine/min/mg of protein. The relative mRNA levels are expressed as target gene/β-actin ratio. All data are presented as mean ± SEM (Wilcoxon matched pairs test).