Table 4 Observed and Expected genotype frequencies and the HardyWeinberg Equilibrium in the control population
SNP | Controls (n) | Observed Genotype Frequency | Allele Frequency (in %) | Expected Genotype Frequency | Chi-square Goodness of fit test statistic (p value) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
1:1 | 1:2 | 2:2 | 1 | 2 | 1:1 | 1:2 | 2:2 | 2:2 | ||
IL1A +4845 | 498 | 215 | 245 | 38 | 67.8 | 32.2 | 229 | 217 | 52 | χ2 = 7.49; p = 0.01 |
IL1B -511 | 489 | 232 | 206 | 51 | 66.5 | 31.5 | 230 | 211 | 48 | χ2 = 0.20; p = 0.66 |
IL1B +3954 | 420 | 231 | 167 | 22 | 74.9 | 25.1 | 235 | 158 | 27 | χ2 = 1.13; p = 0.29 |
IL1RN +2018 | 490 | 247 | 202 | 41 | 71 | 29 | 247 | 202 | 41 | χ2 = 0; p = 0.95 |
IL4R +1902 | 767 | 451 | 288 | 28 | 77.6 | 22.4 | 461 | 267 | 39 | χ2 = 4.45; p = 0.03 |
IL6 -174 | 490 | 168 | 235 | 87 | 58.3 | 41.7 | 167 | 238 | 85 | χ2 = 0.06; p = 0.81 |
IL10 -1082 | 498 | 117 | 260 | 121 | 49.6 | 50.4 | 123 | 249 | 126 | χ2 = 0.85; p = 0.36 |