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Table 3 Nuclear pleomorphism and MIB-1 counts in relation to the number of abnormal findings in Bcl-2, p27 and p53 protein expressions.

From: Bcl-2 protein expression is associated with p27 and p53 protein expressions and MIB-1 counts in breast cancer

No. of abnormal findings in Bcl-2, p27 and p53 protein expressions* No. of patients Nuclear grade ** MIB-1 counts ***
   I or II III negative positive
no 97 92 (95) 5 (5) 76 (78) 21 (22)
one 59 38 (64) 21 (36) 35 (59) 24 (41)
two 58 28 (48) 30 (52) 24 (41) 34 (59)
all (three) 35 10 (29) 25 (71) 12 (34) 23 (66)
  1. * Abnormal findings in Bcl-2 and p27 protein expressions were defined as a decreased expression, while an abnormal finding in p53 protein expression was defined as a positive expression.
  2. ** p < 0.0001, *** p < 0.0001