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Table 3 Nuclear pleomorphism and MIB-1 counts in relation to the number of abnormal findings in Bcl-2, p27 and p53 protein expressions.

From: Bcl-2 protein expression is associated with p27 and p53 protein expressions and MIB-1 counts in breast cancer

No. of abnormal findings in Bcl-2, p27 and p53 protein expressions*

No. of patients

Nuclear grade **

MIB-1 counts ***

  

I or II

III

negative

positive

no

97

92 (95)

5 (5)

76 (78)

21 (22)

one

59

38 (64)

21 (36)

35 (59)

24 (41)

two

58

28 (48)

30 (52)

24 (41)

34 (59)

all (three)

35

10 (29)

25 (71)

12 (34)

23 (66)

  1. * Abnormal findings in Bcl-2 and p27 protein expressions were defined as a decreased expression, while an abnormal finding in p53 protein expression was defined as a positive expression.
  2. ** p < 0.0001, *** p < 0.0001