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Table 4 Clinicopathological characteristics of gastric cancers according to the level of loss of heterozygosity (LOH) and microsatellite instability*

From: The 5'-end transitional CpGs between the CpG islands and retroelements are hypomethylated in association with loss of heterozygosity in gastric cancers

  Total High LOH Low LOH p† Baseline LOH Microsatellite instability
No. of patients 50 20 19   6 5
Age (years)       
   Mean ± SD 59.6 ± 12.6 60.5 ± 11.7 61.1 ± 11.6 0.883 55.0 ± 7.9 66.8 ± 7.3
Tumor size (cm)       
   Mean ± SD 4.9 ± 2.8 5.2 ± 2.7 4.4 ± 3.1 0.402 4.3 ± 1.8 6.3 ± 3.2
Sex       
   Male 32 15 12 0.325 3 2
   Female 18 5 7   3 3
Lauren classification       
   Intestinal 29 10 16 0.032 0 3
   Diffuse 11 5 3   3 0
   Mixed 10 5 0   3 2
Differentiation       
   Well 4 0 3 0.046 0 1
   Moderate 26 11 13   0 2
   Poor 20 9 3   6 2
Growth pattern       
   Infiltrative 27 14 9 0.126 2 2
   Expanding 3 0 3   0 0
   Mixed 20 6 7   4 3
Venous invasion       
   Yes 6 4 0 0.059 2 0
   No 44 16 19   4 5
Lymphatic invasion       
   Yes 29 16 5 0.001 5 3
   No 21 4 14   1 2
Tumor stage       
   Early stage 29 8 15 0.015 2 4
   Advanced stage 21 12 4   4 1
  1. *The classification of microsatellite genotypes is detailed in the "Material and Method" section.
  2. †p values were calculated between the low LOH and high LOH cases by an independent t test for the age and tumor size variables and by a Fisher's exact test or a χ 2test for other variables.