Table 1 Characteristics of primary tumor and metastatic disease according to age (%)
Characteristic | Age at time of diagnosis of primary tumor | Â | |||||
|---|---|---|---|---|---|---|---|
|  | 20–49 (n = 34) | 50–69 (n = 62) | 70+ (n = 20) | p-value | |||
| Â | No. | (%) | No. | (%) | No. | (%) | Â |
Tumor size | |||||||
   T1 | 15 | (44) | 27 | (43) | 7 | (35) | 0.60 |
   T2 | 16 | (47) | 25 | (40) | 7 | (35) |  |
   T3 | 0 | (0) | 1 | (2) | 0 | (0) |  |
   T4 | 3 | (8) | 8 | (12) | 6 | (30) |  |
   Tx | 0 | (0) | 1 | (2) | 0 | (0) |  |
Lymph node status | |||||||
   N+ | 19 | (55) | 32 | (51) | 8 | (40) | 0.65 |
   N- | 11 | (32) | 21 | (33) | 6 | (30) |  |
   Unknown | 4 | (11) | 9 | (14) | 6 | (30) |  |
Metastasis | |||||||
   M0 | 31 | (91) | 55 | (88) | 19 | (95) | 0.91 |
   M1 | 3 | (8) | 7 | (11) | 1 | (5) |  |
Histology | |||||||
   ductal | 21 | (61) | 35 | (56) | 14 | (70) | 0.89 |
   lobular or mixed | 9 | (25) | 19 | (29) | 3 | (20) |  |
   other | 4 | (11) | 8 | (12) | 3 | (10) |  |
Primary therapy | |||||||
   surgery | 33 | (97) | 59 | (95) | 19 | (95) | 1.00 |
   radiotherapy | 25 | (73) | 42 | (67) | 14 | (70) | 0.86 |
   systemic therapy | 21 | (61) | 36 | (58) | 14 | (70) | 0.64 |
   other | 0 | (0) | 1 | (1) | 0 | (0) | - |
Metastatic disease | |||||||
Interval (months) from diagnosis primary tumor until diagnosis of metastatic disease | Â | Â | Â | Â | Â | Â | Â |
   Median (range) | 25 (14–47) | 42 (17–73) | 23 (14–48.5) | 0.07 | |||
Interval from diagnosis of metastatic disease until death | Â | Â | Â | Â | Â | Â | Â |
   Median (range) | 21 (11–45) | 22 (9–50) | 12 (6–31.5) | 0.048 | |||
First site of metastatic disease | |||||||
   bone | 14 | (41) | 18 | (29) | 5 | (25) | 0.21 |
   lung and/or pleura | 9 | (26) | 20 | (32) | 8 | (40) |  |
   abdominal viscera | 3 | (8) | 12 | (19) | 1 | (5) |  |
   other | 8 | (23) | 12 | (19) | 6 | (30) |  |
All metastatic sites (until death) | |||||||
   bone | 27 | (79) | 43 | (69) | 11 | (55) | 0.16 |
   lung and/or pleura | 16 | (47) | 31 | (50) | 11 | (55) | 0.32 |
   abdominal viscera | 20 | (58) | 33 | (53) | 5 | (25) | 0.16 |
   central nervous system | 15 | (44) | 11 | (17) | 1 | (5) | 0.001 |
   skin | 6 | (18) | 12 | (19) | 5 | (25) | 0.80 |
   other | 9 | (26) | 14 | (23) | 4 | (20) | 0.88 |
Co-morbid conditions | |||||||
   Previous cancer | 1 | (3) | 2 | (3) | 2 | (10) | 0.46 |
   Lung disease* | 5 | (15) | 8 | (13) | 5 | (25) | 0.45 |
   Cardiovascular disease** | 1 | (3) | 23 | (37) | 12 | (60) | <0.0001 |
   Diabetes | 0 | (0) | 5 | (8) | 7 | (35) | 0.0002 |