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Table 3 Ras family, Braf and PIK3CA in Murine Neuroblastomas

From: Mutations in PIK3CAare infrequent in neuroblastoma

TH-MYCN NB*

MYCN**

Hras1

Kras2

Nras

Braf

PIK3CA

1

+++

wt

wt

wt

wt

wt

2

+++

wt

wt

wt

wt

wt

3

+++

wt

wt

wt

wt

wt

4

+++

wt

wt

wt

wt

wt

5

+++

wt

wt

wt

wt

wt

6

+++

wt

wt

wt

wt

wt

7

+++

wt

wt

wt

wt

wt

8

+++

wt

wt

wt

wt

wt

9

+++

wt

wt

wt

wt

wt

10

+++

wt

wt

wt

wt

wt

11

+++

wt

wt

wt

wt

wt

12

+++

wt

wt

wt

wt

wt

13

+++

wt

wt

wt

wt

wt

14

+++

wt

wt

wt

wt

wt

15

+++

wt

wt

wt

wt

wt

16

+++

wt

wt

wt

wt

wt

17

+++

wt

Y32Y

wt

wt

wt

18

+++

wt

wt

wt

wt

wt

19

+++

wt

wt

wt

wt

wt

20

+++

wt

wt

wt

wt

wt

21

+++

S65S

Y32Y

A18A

wt

wt

22T

+++

wt

wt

wt

wt

wt

23T

+++

wt

wt

wt

wt

wt

24T

+++

wt

wt

wt

wt

wt

25

+++

wt

wt

wt

wt

wt

  1. wt; wild-type sequence.
  2. * T denotes thoracic tumor (all others are retroperitoneal/abdominal).
  3. ** MYCN transgene overexpressed in neural crest tissues.