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Table 3 Ras family, Braf and PIK3CA in Murine Neuroblastomas

From: Mutations in PIK3CAare infrequent in neuroblastoma

TH-MYCN NB* MYCN** Hras1 Kras2 Nras Braf PIK3CA
1 +++ wt wt wt wt wt
2 +++ wt wt wt wt wt
3 +++ wt wt wt wt wt
4 +++ wt wt wt wt wt
5 +++ wt wt wt wt wt
6 +++ wt wt wt wt wt
7 +++ wt wt wt wt wt
8 +++ wt wt wt wt wt
9 +++ wt wt wt wt wt
10 +++ wt wt wt wt wt
11 +++ wt wt wt wt wt
12 +++ wt wt wt wt wt
13 +++ wt wt wt wt wt
14 +++ wt wt wt wt wt
15 +++ wt wt wt wt wt
16 +++ wt wt wt wt wt
17 +++ wt Y32Y wt wt wt
18 +++ wt wt wt wt wt
19 +++ wt wt wt wt wt
20 +++ wt wt wt wt wt
21 +++ S65S Y32Y A18A wt wt
22T +++ wt wt wt wt wt
23T +++ wt wt wt wt wt
24T +++ wt wt wt wt wt
25 +++ wt wt wt wt wt
  1. wt; wild-type sequence.
  2. * T denotes thoracic tumor (all others are retroperitoneal/abdominal).
  3. ** MYCN transgene overexpressed in neural crest tissues.