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Table 1 PIK3CA in Primary Human Neuroblastomas

From: Mutations in PIK3CAare infrequent in neuroblastoma

Primary NB Age (mos.) INSS stage MYCN Tumor PIK3CAstatus* Constitutional PIK3CAstatus
#1347 1.4 1 S wt (het. G19361A; intron 8) -
#1354 10.5 1 S wt -
#1344 11.7 1 S wt -
#1260 13.5 1 S wt -
#1308 23.2 1 S wt -
#1334 25.5 1 S wt (het. T19623G; intron 9) -
#1127 52.8 1 S wt -
#354 71.9 1 AMP wt (het. C19339T; intron 8) -
#1248 2.3 2 S wt -
#1087 16.4 2 S wt -
#1142 48.7 2 S wt -
#1281 82.9 2 S wt -
#190 104.0 2 AMP wt -
#1330 20.0 2 S wt -
#1339 50.0 2 S wt -
#0157 178.1 2 AMP wt (het. C19339T; intron 8) -
#1137 4.5 3 AMP wt -
#1290 7.9 3 S wt -
#1345 12.2 3 S wt -
#1258 21.1 3 S wt -
#1070 23.4 3 AMP E982D (+het. C19339T; intron 8) wt (+het. C19339T; intron 8)
#1223 35.8 3 AMP wt -
#1289 2.5 4 S wt -
#1302 2.6 4 S wt (het. T19623G; intron 9) -
#1259 3.2 4 S wt (het. C19339T; intron 8) -
#1066 6.7 4 AMP wt (het. C19339T; intron 8) -
#1304 8.9 4 S wt -
#1068 13.5 4 AMP wt -
#1243 19.2 4 AMP wt -
#1266 23.3 4 AMP wt -
#1198 24.0 4 AMP wt -
#1287 24.9 4 AMP wt (het. T19623G; intron 9) -
#1210 33.4 4 S wt -
#1204 36.8 4 S wt -
#1218 37.8 4 S wt (het. T35577C in 3'-UTR) wt (het. T35577C in 3'-UTR)
#1213 40.5 4 S wt -
#1263 40.7 4 AMP wt -
#1236 46.3 4 S wt -
#1337 50.0 4 S wt -
#1246 52.1 4 AMP wt -
#1288 54.2 4 AMP wt (het. T19623G; intron 9) -
#1220 60.3 4 S wt -
  1. INSS; International Neuroblastoma Staging System.
  2. AMP; MYCN genomic amplification.
  3. S; single-copy MYCN per haploid genome.
  4. wt; wild-type sequence
  5. * Nucleotide position referenced from genomic sequence 1st nucleotide of exon 1.