Table 5 Associations between estrogen receptor-beta (ESR2) polymorphisms and breast cancer risk in the BBD cohort
| Â | Â | Cancer | No Cancer | Â | Â | ||
|---|---|---|---|---|---|---|---|
| Â | Â | (n = 91) | (n = 1347) | All Participants | Post-menopausal Only | ||
| Â | dbSNP rs# | n | % | n | % | Age- Adjusted OR (95% CI) | Age-Adjusted OR (95% CI) |
ESR2 38 bp 3' of STP | 4986938 | Â | Â | Â | Â | Â | Â |
   GG |  | 26 | 28.6 | 470 | 34.9 | 1.00 | 1.00 |
   GA |  | 43 | 47.3 | 612 | 45.4 | 1.27 (0.77, 2.10) | 1.46 (0.80, 2.68) |
   AA |  | 19 | 20.9 | 190 | 14.1 | 1.83 (0.99, 3.38) | 1.71 (0.78, 3.76) |
p-for-trend | Â | Â | Â | Â | Â | 0.06 | 0.1 |
   GA/AA |  | 62 | 68.1 | 802 | 59.5 | 1.40 (0.88, 2.25) | 1.52 (0.85, 2.71) |
   Missing |  | 3 | 3.3 | 75 | 5.6 |  |  |
ESR2 5659 bp 3' of STP | 928554 | Â | Â | Â | Â | Â | Â |
   GG |  | 10 | 11.0 | 202 | 15.0 | 1.00 | 1.00 |
   GA |  | 44 | 48.4 | 632 | 46.9 | 1.41 (0.70, 2.86) | 1.04 (0.48, 2.26) |
   AA |  | 28 | 30.8 | 419 | 31.1 | 1.38 (0.66, 2.89) | 0.88 (0.38, 2.05) |
   GA/AA |  | 72 | 79.1 | 1051 | 78.0 | 1.40 (0.71, 2.76) | 0.98 (0.47, 2.06) |
   Missing |  | 9 | 9.9 | 94 | 7.0 |  |  |
ESR2 5696 bp 3' of STP | none | Â | Â | Â | Â | Â | Â |
   AA |  | 75 | 82.4 | 1101 | 81.7 | 1.00 | 1.00 |
   AG |  | 12 | 13.2 | 180 | 13.4 | 0.96 (0.51, 1.81) | 0.74 (0.33, 1.67) |
   GG |  | 1 | 1.1 | 4 | 0.3 | 3.68 (0.41, 33.37) | -- |
   AG/GG |  | 13 | 14.3 | 184 | 13.7 | 1.02 (0.56, 1.88) | 0.73 (0.33, 1.64) |
   Missing |  | 3 | 3.3 | 62 | 4.6 |  |  |
ESR2 5772 bp 3' of STP | 8018687 | Â | Â | Â | Â | Â | Â |
   AA |  | 86 | 94.5 | 1133 | 84.1 | 1.00 | 1.00 |
   AG |  | 5 | 5.5 | 169 | 12.5 | 0.39 (0.16, 0.99) | 0.62 (0.24, 1.59) |
   GG |  | 0 | 0.0 | 5 | 0.4 | -- | -- |
   AG/GG |  | 5 | 5.5 | 174 | 12.9 | 0.38 (0.15, 0.96) | 0.61 (0.24, 1.55) |
   Missing |  | 0 | 0.0 | 40 | 3.0 |  |  |