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Table 5 Associations between estrogen receptor-beta (ESR2) polymorphisms and breast cancer risk in the BBD cohort

From: Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease

   Cancer No Cancer   
   (n = 91) (n = 1347) All Participants Post-menopausal Only
  dbSNP rs# n % n % Age- Adjusted OR (95% CI) Age-Adjusted OR (95% CI)
ESR2 38 bp 3' of STP 4986938       
   GG   26 28.6 470 34.9 1.00 1.00
   GA   43 47.3 612 45.4 1.27 (0.77, 2.10) 1.46 (0.80, 2.68)
   AA   19 20.9 190 14.1 1.83 (0.99, 3.38) 1.71 (0.78, 3.76)
p-for-trend       0.06 0.1
   GA/AA   62 68.1 802 59.5 1.40 (0.88, 2.25) 1.52 (0.85, 2.71)
   Missing   3 3.3 75 5.6   
ESR2 5659 bp 3' of STP 928554       
   GG   10 11.0 202 15.0 1.00 1.00
   GA   44 48.4 632 46.9 1.41 (0.70, 2.86) 1.04 (0.48, 2.26)
   AA   28 30.8 419 31.1 1.38 (0.66, 2.89) 0.88 (0.38, 2.05)
   GA/AA   72 79.1 1051 78.0 1.40 (0.71, 2.76) 0.98 (0.47, 2.06)
   Missing   9 9.9 94 7.0   
ESR2 5696 bp 3' of STP none       
   AA   75 82.4 1101 81.7 1.00 1.00
   AG   12 13.2 180 13.4 0.96 (0.51, 1.81) 0.74 (0.33, 1.67)
   GG   1 1.1 4 0.3 3.68 (0.41, 33.37) --
   AG/GG   13 14.3 184 13.7 1.02 (0.56, 1.88) 0.73 (0.33, 1.64)
   Missing   3 3.3 62 4.6   
ESR2 5772 bp 3' of STP 8018687       
   AA   86 94.5 1133 84.1 1.00 1.00
   AG   5 5.5 169 12.5 0.39 (0.16, 0.99) 0.62 (0.24, 1.59)
   GG   0 0.0 5 0.4 -- --
   AG/GG   5 5.5 174 12.9 0.38 (0.15, 0.96) 0.61 (0.24, 1.55)
   Missing   0 0.0 40 3.0