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Table 3 Associations between estrogen metabolizing polymorphisms and breast cancer risk in the BBD cohort

From: Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease

   Cancer No Cancer   
  dbSNP rs# (n = 91) (n = 1347) All Participants Post-menopausal Only
   n % n % Age- Adjusted OR (95% CI) Age- Adjusted OR (95% CI)
COMT Val158Met 4680       
   GG   16 17.6 272 20.2 1.00 1.00
   GA   41 45.1 608 45.1 1.15 (0.63, 2.08) 0.89 (0.45, 1.77)
   AA   24 26.4 371 27.5 1.10 (0.57, 2.11) 0.90 (0.43, 1.90)
   GA/AA   65 71.4 979 72.7 1.13 (0.64, 1.98) 0.89 (0.47, 1.70)
   Missing   10 11.0 96 7.1   
CYP1A1 Ile462Val 1048943       
   AA   78 85.7 1233 91.5 1.00 1.00
   AG   7 7.7 80 5.9 1.38 (0.62, 3.10) 1.30 (0.45, 3.74)
   GG   1 1.1 5 0.4 3.33 (0.38, 28.99) 8.33 (0.74, 93.62)
p-for-trend       0.20 0.20
   AG/GG   8 8.8 85 6.3 1.49 (0.70, 3.19) 1.56 (0.60, 4.08)
   Missing   5 5.5 29 2.2   
CYP1B1 Asn453Ser 1800440       
   AA   51 56.0 866 64.3 1.00 1.00
   AG   31 34.1 358 26.6 1.45 (0.91, 2.31) 1.51 (0.87, 2.65)
   GG   4 4.4 37 2.7 1.77 (0.61, 5.16) 2.44 (0.81, 7.36)
p-for-trend       0.08 0.05
   AG/GG   35 38.5 395 29.3 1.48 (0.95, 2.32) 1.61 (0.94, 2.74)
   Missing   5 5.5 86 6.4   
CYP1B1 Arg48Gly 10012       
   CC   39 42.9 600 44.5 1.00 1.00
   CG   33 36.3 460 34.1 1.10 (0.68, 1.78) 0.95 (0.53, 1.69)
   GG   3 3.3 76 5.6 0.60 (0.18, 2.00) 0.25 (0.03, 1.88)
   CG/GG   36 39.6 536 39.8 1.02 (0.65, 1.64) 0.84 (0.48, 1.50)
   Missing   16 17.6 211 15.7   
CYP1B1 Val432Leu 1056836       
   CC   25 27.5 365 27.1 1.00 1.00
   CG   39 42.9 653 48.5 0.88 (0.53, 1.48) 1.04 (0.56, 1.98)
   GG   17 18.7 270 20.0 0.93 (0.49, 1.76) 0.93 (0.41, 2.09)
   CG/GG   56 61.5 923 68.5 0.90 (0.55, 1.46) 1.01 (0.56, 1.85)
   Missing   10 11.0 59 4.4