Table 3 Associations between estrogen metabolizing polymorphisms and breast cancer risk in the BBD cohort
| Â | Â | Cancer | No Cancer | Â | Â | ||
|---|---|---|---|---|---|---|---|
| Â | dbSNP rs# | (n = 91) | (n = 1347) | All Participants | Post-menopausal Only | ||
| Â | Â | n | % | n | % | Age- Adjusted OR (95% CI) | Age- Adjusted OR (95% CI) |
COMT Val158Met | 4680 | Â | Â | Â | Â | Â | Â |
   GG |  | 16 | 17.6 | 272 | 20.2 | 1.00 | 1.00 |
   GA |  | 41 | 45.1 | 608 | 45.1 | 1.15 (0.63, 2.08) | 0.89 (0.45, 1.77) |
   AA |  | 24 | 26.4 | 371 | 27.5 | 1.10 (0.57, 2.11) | 0.90 (0.43, 1.90) |
   GA/AA |  | 65 | 71.4 | 979 | 72.7 | 1.13 (0.64, 1.98) | 0.89 (0.47, 1.70) |
   Missing |  | 10 | 11.0 | 96 | 7.1 |  |  |
CYP1A1 Ile462Val | 1048943 | Â | Â | Â | Â | Â | Â |
   AA |  | 78 | 85.7 | 1233 | 91.5 | 1.00 | 1.00 |
   AG |  | 7 | 7.7 | 80 | 5.9 | 1.38 (0.62, 3.10) | 1.30 (0.45, 3.74) |
   GG |  | 1 | 1.1 | 5 | 0.4 | 3.33 (0.38, 28.99) | 8.33 (0.74, 93.62) |
p-for-trend | Â | Â | Â | Â | Â | 0.20 | 0.20 |
   AG/GG |  | 8 | 8.8 | 85 | 6.3 | 1.49 (0.70, 3.19) | 1.56 (0.60, 4.08) |
   Missing |  | 5 | 5.5 | 29 | 2.2 |  |  |
CYP1B1 Asn453Ser | 1800440 | Â | Â | Â | Â | Â | Â |
   AA |  | 51 | 56.0 | 866 | 64.3 | 1.00 | 1.00 |
   AG |  | 31 | 34.1 | 358 | 26.6 | 1.45 (0.91, 2.31) | 1.51 (0.87, 2.65) |
   GG |  | 4 | 4.4 | 37 | 2.7 | 1.77 (0.61, 5.16) | 2.44 (0.81, 7.36) |
p-for-trend | Â | Â | Â | Â | Â | 0.08 | 0.05 |
   AG/GG |  | 35 | 38.5 | 395 | 29.3 | 1.48 (0.95, 2.32) | 1.61 (0.94, 2.74) |
   Missing |  | 5 | 5.5 | 86 | 6.4 |  |  |
CYP1B1 Arg48Gly | 10012 | Â | Â | Â | Â | Â | Â |
   CC |  | 39 | 42.9 | 600 | 44.5 | 1.00 | 1.00 |
   CG |  | 33 | 36.3 | 460 | 34.1 | 1.10 (0.68, 1.78) | 0.95 (0.53, 1.69) |
   GG |  | 3 | 3.3 | 76 | 5.6 | 0.60 (0.18, 2.00) | 0.25 (0.03, 1.88) |
   CG/GG |  | 36 | 39.6 | 536 | 39.8 | 1.02 (0.65, 1.64) | 0.84 (0.48, 1.50) |
   Missing |  | 16 | 17.6 | 211 | 15.7 |  |  |
CYP1B1 Val432Leu | 1056836 | Â | Â | Â | Â | Â | Â |
   CC |  | 25 | 27.5 | 365 | 27.1 | 1.00 | 1.00 |
   CG |  | 39 | 42.9 | 653 | 48.5 | 0.88 (0.53, 1.48) | 1.04 (0.56, 1.98) |
   GG |  | 17 | 18.7 | 270 | 20.0 | 0.93 (0.49, 1.76) | 0.93 (0.41, 2.09) |
   CG/GG |  | 56 | 61.5 | 923 | 68.5 | 0.90 (0.55, 1.46) | 1.01 (0.56, 1.85) |
   Missing |  | 10 | 11.0 | 59 | 4.4 |  |  |