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Table 5 Association between XRCC1 condon 194 and 399 polymorphisms and NPC risk stratified by age range (yr)

From: Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population

Genotype <60 ≥60
  Cases Controls Adjusted ORa (95% CI) P value Cases Controls Adjusted ORa (95%CI) P value
XRCC1 Arg194Trp
   Arg/Arg 189 190 1.00   42 45 1.00  
   Arg/Trp 151 179 0.85(0.62–1.16) 0.30 17 38 0.48(0.23–0.99) 0.05*
   Trp/Trp 17 37 0.52(0.28–0.96) 0.04 1 6 0.27(0.03–2.52) 0.25
XRCC1 Arg399Gln
   Arg/Arg 210 228 1.00   27 42 1.00  
   Arg/Gln 131 159 0.83(0.61–1.13) 0.23 25 41 0.84(0.38–1.86) 0.67
Gln/Gln 22 25 1.09(0.58–2.05) 0.79 10 6 1.75(0.48–6.44) 0.40
  1. aAdjust OR were calculated with the XRCC1 194Arg/Arg or 399Arg/Arg genotype as the reference group and adjusted for sex, smoking status.
  2. *P-value was not significant after Bonferroni's correction.