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Table 3 Association between XRCC1 condon 194 and 399 polymorphisms and NPC risk stratified by gender

From: Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population

Genotype Male Female
  Cases Controls Adjusted ORa (95% CI) P value Cases Controls Adjusted ORa (95% CI) P value
XRCC1 Arg194Trp
   Arg/Arg 175 120 1.00   57 115 1.00  
   Arg/Trp 121 106 0.77(0.54–1.10) 0.16 45 111 0.78(0.46–1.33) 0.36
   Trp/Trp 10 21 0.32(0.14–0.70) 0.004* 9 22 1.11(0.47–2.61) 0.82
XRCC1 Arg399Gln
   Arg/Arg 177 130 1.00   64 140 1.00  
   Arg/Gln 114 105 0.81(0.57–1.15) 0.24 38 95 0.82(0.47–1.43) 0.48
Gln/Gln 22 15 1.04(0.52–2.11) 0.91 10 15 1.28(0.49–3.36) 0.62
  1. aAdjust OR were calculated with the XRCC1 194Arg/Arg or 399Arg/Arg genotype as the reference group and adjusted for age, smoking.
  2. * P-value remained significant after Bonferroni's correction.