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Table 2 Association between risk of NPC and XRCC1 genotypes among cases and controls

From: Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population

Genotype Cases No. (%)a Controls No. (%)b Unadjusted OR Adjusted ORc (95%CI) P value
XRCC1Arg194Trp
   Arg/Arg 232(55.7) 235 (47.5) 1.00 1.00  
   Arg/Trp 166(39.8) 217(43.8) 0.80 0.79(0.60–1.05) 0.10
   Trp/Trp 19(4.5) 43(8.7) 0.48 0.48(0.27–0.86) 0.01*
   Allele of Trp 0.24 0.31    
XRCC1 Arg399Gln
   Arg/Arg 241(56.7) 270(53.9) 1.00 1.00  
   Arg/Gln 152(35.8) 201(40.1) 0.81 0.82(0.62–1.08) 0.16
Gln/Gln 32(7.5) 30(6.0) 1.20 1.20(0.69–2.06) 0.53
   Allele of Gln 0.25 0.26    
  1. a 417 cases and 495 controls were eligible tested in condon 194 genotype variant.
  2. b 425 cases and 501 controls were eligible tested in condon 399 genotype variant.
  3. c Adjusted OR were calculated with the XRCC1 194Arg/Arg or 399Arg/Arg genotype as the reference group and adjusted for age, sex, smoking status.
  4. *P-value remained significant after Bonferroni's correction.