Angiomotins in nodal status (top panel, A-C) and predicted prognosis (bottom panel, E-F). A and D: angiomotin, B and E: angiomotin-like-1, C and F: angiomotin-like-2. A, B AND C : difference between node negative and node positive tumours. * p < 0.01 vs node negative tumours. D, E &F: angiomotins and predicted clinical outcome based on Nottingham Prognostic Index (NPI = (0.2 × size) + grade + Nodal status). NPI<3.4, 3.4–5.4 and >5.4 represented good (15 year survival rate 80%) (NPI1), moderate (15 year survival 42%) (NPI2) and poor prognosis (15 year survival 15%). Inserts: respective angiomotin transcript:CK19 transcript ratio.