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Table 2 List of genes identified in the microarray analysis between HeLa Tet-off cells harboring pTIG-TSPY and those harboring the vector pTIG alone
| Gene | GenBank ID | Expression | Remarks |
|---|---|---|---|
| TSPY1 | NM_003308 | 26.5 | Testis specific protein, Y-linked, stably transfected gene in the cells |
| MAP2 | NM_002374 | 3.41 | Microtubule-associated protein 2, neurogenesis and tumorigenesis |
| RGC32 | NM_014059 | 2.56 | Response gene to complement 32, deregulation of cell cycle required for tumor cell growth |
| PDGFC | NM_016205 | 2.32 | Platelet derived growth factor C, a mitogenic factor |
| MAP1B | NM_005909 | 1.93 | Microtubule-associated protein 1B, structural protein, neural development, predictor for breast cancer |
| EFEMP1 | NM_004105 | 1.79 | EGF-containing fibulin-like extracellular matrix protein 1, growth factor |
| G1P2 | NM_005101 | 1.72 | α-interferon inducible protein, IFI-15K, facilitates viral growth |
| LUM | NM_002345 | 1.62 | Lumican, epithelial cell migration and tissue repair |
| NANOS1 | NM_199461 | 1.57 | Human nanos homolog (of Drosophila), germ stem cell development expressed in spermatogonia and spermatocytes in human testis |
| WNT5A | NM_003392 | 1.55 | Wingless-type MMTV integration site family member 5A, Wnt gene family, implicated in oncogenesis and embryogenesis |
| CD24 | NM_013230 | 1.55 | Small cell lung carcinoma cluster 4 antigen, high expression in SCLC |
| TMTC1 | NM_175861 | 1.53 | Transmembrane and tetratricopeptide repeats containing 1, multi-functional, possibly involved in regulation of cell cycle and/or mitosis. |
| CCND2 | NM_001759 | 1.46 | Cyclin D2 complexes with CDK4 or CDK6, G1/S transition, amplified and over-expresses in numerous types of tumors |
| RAP1A | NM_002884 | 1.44 | RAS oncogene family member |
| EGFR | NM_005228 | 1.41 | Epidermal growth factor receptor (ERBB oncogene), cell proliferation, amplified and expresses at high levels in many tumors |
| ANKRD15 | NM_015158 | 1.38 | Ankyrin repeat domain 15, tumor cell growth in renal cell carcinoma |
| GSPT1 | NM_002094 | 1.32 | G1 to S phase transition 1, an inhibitor of apoptosis |
| EP300 | NM_001429 | 1.26 | E1A binding protein p300, a co-factor for hypoxia inducible factor 1A |
| CDKN2B | NM_004936 | 0.71 | Cyclin-dependent kinase inhibitor 2B (p15), binds to and prevents CDK4/CDK6 activation and G1/S progression, tumor suppressor |
| CUL1 | NM_003592 | 0.68 | Cullin 1, involves in deneddylation and modulates G1/S transition |
| TGFB3 | NM_003239 | 0.67 | Transforming growth factor, b3, suppresses tumor formation and blocks cell cycle progression |
| PTN | NM_002825 | 0.66 | Pleiotrophin, neurite growth promoting factor 1, down-regulated in breast cancer |
| TIMP1 | NM_003254 | 0.64 | Tissue inhibitor of metalloproteinase 1, suppresses tumor growth and metastasis |
| DUSP5 | NM_004419 | 0.58 | Dual specificity phosphatase 5, inactivates kinases by dephosphorylation, and negatively regulates MAP kinases |
| SPARC | NM_003118 | 0.56 | Secreted protein, acidc cysteine-rich (osteonectin), loss of expression in lung cancers, regulates cell proliferation |
| CLU | NM_001831 | 0.56 | Clusterin, proapoptotic in colon cancer, down-regulated in CaP |
| IGFBP3 | NM_000598 | 0.49 | Insulin-like growth factor binding protein 3, pro-apoptotic, its inactivation or repression is essential for growth of various tumors |
