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Table 5 Association between exposure categories and progesterone receptor expression

From: Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study

Explanatory Variable Controls Cases with tumors expressing PR* in 0 to 25% of cells Cases with tumors expressing PR* in = order 25 to 100% of cells
  n n OR (95% CI)† n OR (95% CI)†
OC* use
Never 103 15 Referent 33 Referent
Ever 183 31 3.2 (1.3 – 8.0) 64 1.1 (0.6 – 1.9)
HRT* use in post-menopausal women
Never 58 15 Referent 23 Referent
Ever 114 22 0.8 (0.4 – 1.6) 41 0.9 (0.5 – 1.6)
Current menstrual status
Menstruating 114 9 Referent 33 Referent
Post-menopausal 172 37 2.7 (1.2 – 5.8) 64 1.3 (0.8 – 2.1)
Menstrual status 10 years before reference date
Menstruating 158 21 Referent 62 Referent
Post-menopausal 126 23 0.5 (0.2 – 1.5) 35 0.5 (0.2 – 1.0)
Current menstrual status
Menstruating 72 4 Referent 17 Referent
Post-menopausal and not using HRT 58 15 2.4 (1.2 – 5.8) 23 3.1 (1.1 – 8.6)
Menstrual status 10 years before reference date
Menstruating 83 8 Referent 27 Referent
Post-menopausal and not using HRT 46 10 0.3 (0.1 – 2.5) 13 0.8 (0.5 – 1.3)
Smoking status 10 years before reference date
Non-smoker 144 29 Referent 48 Referent
Smoker 142 17 0.5 (0.3 – 1.0) 49 1.0 (0.6 – 1.5)
Body Mass Index on reference date
< 25 156 23 Referent 45 Referent
25 – 30 66 12 1.2 (0.5 – 2.5) 22 1.1 (0.5 – 2.4)
≥ 30 64 11 1.1 (0.6 – 2.0) 29 1.5 (0.8 – 2.6)
Number of live births
None 58 2 Referent 16 Referent
1 28 5 4.0 (0.7 – 22.3) 17 2.1 (0.9 – 4.9)
≥ 2 200 39 4.3 (1.0 – 18.8) 64 1.1 (0.6 – 2.2)
  1. *PR, progesterone receptor; OC, oral contraceptive; HRT, hormone replacement therapy
  2. † Odds ratio (OR) and 95% confidence intervals (CI) estimated from multivariable polytomous logistic regression including continuous age and three categories of education (high school or less, some college or trade school, and college graduate or graduate school) as confounding variables. None of the tests for linear trend was significant.