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Table 2 Observed EPHB2 germline variations in colorectal cancer and hyperplastic polyposis patients.

From: EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis

Patient Exon nt change aa change Index patient (diagnosis, age at diagnosis, nationality) Family history of cancer LOH Frequency in
        familial PC* familial CRC* healthy controls
C713 3 239G>A R80H CRC, 73 years, FIN brother, PC, 60 years father, GC*, 57 years no - 1/106 9/281
C112 5 1081A>G I361V CRC, 75 years and PC, 73 years, FIN - yes 0/164 0/139 0/239
C809 9 1702C>T R568W serrated CRC, 69 years, FIN father, PC, 82 years no 0/164 0/145 0/279
PAP211 14 2581G>A D861N HPP*, 58 years, UK mother, CRC, 36 years - - 0/40 0/200
  1. * CRC colorectal cancer; HPP hyperplastic polyposis; PC prostate cancer; GC gastric cancer.
  2. frequency in additionally screened 40 UK HPP patients