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Table 2 TSER and TS 3'-UTR del6 genotype frequencies among breast cancer cases and controls

From: Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis

Genotype

Controls (N = 473)

Breast cancer (N = 432)

 

N (%)

N (%)

aAdjusted OR (95% CI)

TSER

3R/3R (reference)

305(64.5)

279(64.6)

1.00

2R/3R

143(30.2)

130(30.1)

0.95(0.70–1.29)

2R/2R

25(5.3)

23(5.3)

1.13(0.61–2.10)

2R/3R and 2R/2R

168(35.5)

153(35.4)

0.98(0.73–1.30)

TS3'-UTR del6

del6/del6 (reference)

216(45.7)

194(44.9)

1.00

del6/ins6

201(42.5)

208(48.1)

1.09(0.82–1.46)

ins6/ins6

56(11.8)

30(6.9)

0.58(0.35–0.97)

  1. a Adjusted for age, age at menarche, menopausal status, BMI and family history of cancer