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Table 1 Percentage of reported EGFR-amplification/overexpression in patients with glioblastoma multiforme: Literature overview. Abbreviations: Southern Blot (SB), Immunohistochemistry (IHC), Western Blot (WB), Polymerase Chain Reaction (PCR), In situ hybridization (ISH), Fluorescence In-Situ Hybridization (FISH).

From: Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT) – phase I/II trial: study protocol

Author (Reference) Year of publication Patients (n) Patients with EGFR-amplification (n) Patients with EGFR-overexpression (n) Method of EGFR evaluation
Quan et al. 2005 107 36 (32%) - ISH
Mellinghoff et al. 2005 25 12 (48%) - FISH, PCR
Shinojima et al. 2003 87 40 (46%) - SB, IHC
Schmidt et al. 2002 91 26 (29%) - PCR
Barker et al. 2001 162 - 53 (33%) IHC
Simmons et al. 2001 110 - 39 (35%) IHC
Chakravarti et al. 2001 56 - 23 (41%) WB
Smith et al. 2001 111 46 (41%) - FISH, PCR
Yoon et al. 2001 36 13 (36%) 12 (33%) PCR, IHC
Korshunov et al. 1999 168 - 102 (61%) IHC
Olson et al. 1998 70 19 (27%) - SB
Bouvier-Labit et al. 1998 63 - 22 (35%) IHC
Newcomb et al. 1998 80 - 28 (35%) IHC
Korkopopoulou et al. 1997 37 - 17 (64%) IHC
Rainov et al. 1997 71 - 54 (76%) IHC
Liu et al. 1997 63 31 (49%) - SB
Waha et al. 1996 54/62 18 (33%) 32 (52%) PCR, IHC
Zhu et al. 1996 55 - 39 (71%) IHC
Diedrich et al. 1995 32/22 13 (41%) 19 (86%) ISH
Kordek et al. 1995 30 - 10 (33%) IHC
Schober et al. 1995 21 13 (62%) - PCR, IHC
Schlegel et al. 1994 42 19 (45%) 27 (64%) SB, PCR, WB
Hiesinger et al. 1993 17 - 4 (24%) IHC
Hurtt et al. 1992 19 6 (32%) - Dot blot
Jaros et al. 1992 20 - 19 (95%) IHC
Torp et al. 1992 20 8 (40%) - SB
Bigner et al. 1988 48 20 (42%) NR SB, slot blot
Wong et al. 1987 47 20 (43%) - SB, slot blot