Table 1 Percentage of reported EGFR-amplification/overexpression in patients with glioblastoma multiforme: Literature overview. Abbreviations: Southern Blot (SB), Immunohistochemistry (IHC), Western Blot (WB), Polymerase Chain Reaction (PCR), In situ hybridization (ISH), Fluorescence In-Situ Hybridization (FISH).
Author (Reference) | Year of publication | Patients (n) | Patients with EGFR-amplification (n) | Patients with EGFR-overexpression (n) | Method of EGFR evaluation |
|---|---|---|---|---|---|
Quan et al. | 2005 | 107 | 36 (32%) | - | ISH |
Mellinghoff et al. | 2005 | 25 | 12 (48%) | - | FISH, PCR |
Shinojima et al. | 2003 | 87 | 40 (46%) | - | SB, IHC |
Schmidt et al. | 2002 | 91 | 26 (29%) | - | PCR |
Barker et al. | 2001 | 162 | - | 53 (33%) | IHC |
Simmons et al. | 2001 | 110 | - | 39 (35%) | IHC |
Chakravarti et al. | 2001 | 56 | - | 23 (41%) | WB |
Smith et al. | 2001 | 111 | 46 (41%) | - | FISH, PCR |
Yoon et al. | 2001 | 36 | 13 (36%) | 12 (33%) | PCR, IHC |
Korshunov et al. | 1999 | 168 | - | 102 (61%) | IHC |
Olson et al. | 1998 | 70 | 19 (27%) | - | SB |
Bouvier-Labit et al. | 1998 | 63 | - | 22 (35%) | IHC |
Newcomb et al. | 1998 | 80 | - | 28 (35%) | IHC |
Korkopopoulou et al. | 1997 | 37 | - | 17 (64%) | IHC |
Rainov et al. | 1997 | 71 | - | 54 (76%) | IHC |
Liu et al. | 1997 | 63 | 31 (49%) | - | SB |
Waha et al. | 1996 | 54/62 | 18 (33%) | 32 (52%) | PCR, IHC |
Zhu et al. | 1996 | 55 | - | 39 (71%) | IHC |
Diedrich et al. | 1995 | 32/22 | 13 (41%) | 19 (86%) | ISH |
Kordek et al. | 1995 | 30 | - | 10 (33%) | IHC |
Schober et al. | 1995 | 21 | 13 (62%) | - | PCR, IHC |
Schlegel et al. | 1994 | 42 | 19 (45%) | 27 (64%) | SB, PCR, WB |
Hiesinger et al. | 1993 | 17 | - | 4 (24%) | IHC |
Hurtt et al. | 1992 | 19 | 6 (32%) | - | Dot blot |
Jaros et al. | 1992 | 20 | - | 19 (95%) | IHC |
Torp et al. | 1992 | 20 | 8 (40%) | - | SB |
Bigner et al. | 1988 | 48 | 20 (42%) | NR | SB, slot blot |
Wong et al. | 1987 | 47 | 20 (43%) | - | SB, slot blot |