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Table 1 Differential gene expression between control cells and cells at different stages of mycoplasma-induced malignant transformation

From: Alteration of gene expression profiles during mycoplasma-induced malignant cell transformation

Gene Class Number of genes
  Screened Expressed in control cells Expressed and altered in cells following mycoplasmal infection
    1 week 11 weeks 18 weeks
    Expressed Increased Decreased Expressed Increased Decreased Expressed Increased Decreased
Apoptosis associated proteins 48 30 34 4 2 27 3 7 25 6 5
Cell adhesion receptors/proteins 100 61 60 6 1 61 9 10 69 12 3
Cell cycle associated proteins 45 34 31 2 4 26 2 9 35 2 5
Cell receptors (by activities) 162 74 90 16 5 90 26 16 70 9 14
Cell signaling, extracellular communication proteins 144 89 82 8 4 98 18 10 112 11 6
Cytoskeleton/motility proteins 59 39 41 4 3 37 8 8 51 6 7
DNA binding and chromatin proteins 44 23 29 5 1 29 6 1 31 8 0
Extracellular transport/carrier proteins 6 4 5 0 0 3 1 0 5 0 0
Extracellular matrix proteins 30 28 29 3 2 29 4 1 27 2 7
Functional unclassified 15 8 11 3 1 13 5 1 13 2 1
Intracellular transducers/effectors/modulators 253 155 158 20 6 149 26 28 201 32 10
Membrane channels, transporters and cell surface antigens 27 16 16 4 1 20 7 0 18 4 1
Metabolism-associated proteins 26 14 16 5 1 18 4 2 20 3 0
Oncogenes and tumor suppressors 65 43 46 3 1 41 6 7 53 8 2
Stress response proteins 39 24 22 1 1 21 3 2 26 2 3
Trafficking/targeting proteins 5 2 1 0 0 2 0 0 3 0 0
Transcription associated proteins 30 27 20 3 4 25 2 3 29 1 0
Translation, post-translation modification and protein turnover 87 65 64 5 6 58 8 9 74 7 5
Total 1185 736 755 92 43 748 138 114 862 115 69