From: Alteration of gene expression profiles during mycoplasma-induced malignant cell transformation
Gene Class | Number of genes | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | Screened | Expressed in control cells | Expressed and altered in cells following mycoplasmal infection | ||||||||
 |  |  | 1 week | 11 weeks | 18 weeks | ||||||
 |  |  | Expressed | Increased | Decreased | Expressed | Increased | Decreased | Expressed | Increased | Decreased |
Apoptosis associated proteins | 48 | 30 | 34 | 4 | 2 | 27 | 3 | 7 | 25 | 6 | 5 |
Cell adhesion receptors/proteins | 100 | 61 | 60 | 6 | 1 | 61 | 9 | 10 | 69 | 12 | 3 |
Cell cycle associated proteins | 45 | 34 | 31 | 2 | 4 | 26 | 2 | 9 | 35 | 2 | 5 |
Cell receptors (by activities) | 162 | 74 | 90 | 16 | 5 | 90 | 26 | 16 | 70 | 9 | 14 |
Cell signaling, extracellular communication proteins | 144 | 89 | 82 | 8 | 4 | 98 | 18 | 10 | 112 | 11 | 6 |
Cytoskeleton/motility proteins | 59 | 39 | 41 | 4 | 3 | 37 | 8 | 8 | 51 | 6 | 7 |
DNA binding and chromatin proteins | 44 | 23 | 29 | 5 | 1 | 29 | 6 | 1 | 31 | 8 | 0 |
Extracellular transport/carrier proteins | 6 | 4 | 5 | 0 | 0 | 3 | 1 | 0 | 5 | 0 | 0 |
Extracellular matrix proteins | 30 | 28 | 29 | 3 | 2 | 29 | 4 | 1 | 27 | 2 | 7 |
Functional unclassified | 15 | 8 | 11 | 3 | 1 | 13 | 5 | 1 | 13 | 2 | 1 |
Intracellular transducers/effectors/modulators | 253 | 155 | 158 | 20 | 6 | 149 | 26 | 28 | 201 | 32 | 10 |
Membrane channels, transporters and cell surface antigens | 27 | 16 | 16 | 4 | 1 | 20 | 7 | 0 | 18 | 4 | 1 |
Metabolism-associated proteins | 26 | 14 | 16 | 5 | 1 | 18 | 4 | 2 | 20 | 3 | 0 |
Oncogenes and tumor suppressors | 65 | 43 | 46 | 3 | 1 | 41 | 6 | 7 | 53 | 8 | 2 |
Stress response proteins | 39 | 24 | 22 | 1 | 1 | 21 | 3 | 2 | 26 | 2 | 3 |
Trafficking/targeting proteins | 5 | 2 | 1 | 0 | 0 | 2 | 0 | 0 | 3 | 0 | 0 |
Transcription associated proteins | 30 | 27 | 20 | 3 | 4 | 25 | 2 | 3 | 29 | 1 | 0 |
Translation, post-translation modification and protein turnover | 87 | 65 | 64 | 5 | 6 | 58 | 8 | 9 | 74 | 7 | 5 |
Total | 1185 | 736 | 755 | 92 | 43 | 748 | 138 | 114 | 862 | 115 | 69 |