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Table 5 Estimated odds-ratios (ORs) and 95% confidence intervals (CIs) associated with the genotype combinations of the four significant two-way SNP-SNP interactions.

From: SNP-SNP interactions in breast cancer susceptibility

SNP-SNP interaction SNP Genotypes Cases n Controls n OR 95% CI
  XPD IL10     
XPD-[Lys751Gln] and IL10-[G(-1082)A] AA AA 40 57 1.0 -
  AC AA 45 39 1.7 [0.9–2.7]
  CC AA 21 8 3.7 [1.6–9.7]
  AA AG 74 89 1.2 [0.8–1.9]
  AC AG 99 71 1.9 [1.3–3.1]
  CC AG 22 22 1.4 [0.8–3.1]
  AA GG 41 26 2.2 [1.3–3.9]
  AC GG 42 50 1.2 [0.7–2.4]
  CC GG 14 10 2.2 [0.8–5.5]
  BARD1 XPD     
BARD1-[Pro24Ser] and XPD-[Lys751Gln] CC AA 66 60 1.0 -
  CT AA 68 90 0.7 [0.4–1.1]
  TT AA 21 22 0.9 [0.4–1.8]
  CC AC 82 67 1.1 [0.7–1.8]
  CT AC 89 69 1.2 [0.7–1.9]
  TT AC 15 24 0.6 [0.3–1.2]
  CC CC 23 13 1.6 [0.7–3.4]
  CT CC 27 26 1.0 [0.5–1.9]
  TT CC 7 1 7.4 [1.3–12.4]
  COMT CCND1     
COMT-[Met108/158Val] and CCND1-[Pro241Pro] AA GG 21 40 1.0 -
  AG GG 57 53 1.9 [1.3–4.6]
  GG GG 25 21 2.4 [1.0–4.9]
  AA AG 48 36 2.6 [1.3–4.5]
  AG AG 110 92 2.3 [1.3–4.5]
  GG AG 38 45 1.6 [1.0–3.2]
  AA AA 22 29 1.4 [0.7–3.3]
  AG AA 43 37 2.2 [1.1–4.3]
  GG AA 34 19 3.3 [1.9–7.2]
  GSTP1 COMT     
GSTP1-[Ile105Val] and COMT-[Met108/158Val] AA AA 30 49 1.0 -
  AG AA 46 48 1.5 [0.9–2.8]
  GG AA 15 8 3.4 [1.1–11.4]
  AA AG 95 92 1.7 [1.0–2.6]
  AG AG 91 69 2.2 [1.4–3.6]
  GG AG 24 21 1.8 [0.9–4.8]
  AA GG 54 36 2.6 [1.4–4.2]
  AG GG 36 41 1.5 [0.9–2.7]
  GG GG 7 8 1.6 [0.5–4.2]
  1. OR and CIs estimated by bootstrap analysis in the 1,000 random samples.