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Table 3 Analysis of individual SNP effects on breast cancer. Estimated odds-ratios (OR) and 95% confidence intervals (CI) associated with each of the 19 polymorphisms selected under co-dominant age-adjusted main effect models (the significant associations are in bold).

From: SNP-SNP interactions in breast cancer susceptibility

SNP Genotype Cases n (%) Controls n (%) OR* 95% CI
COMT AA 94 (23.6) 96 (25.8) 1.0. -
Met108/158Val AG 202 (50.8) 196 (52.7) 1.3 (0.9–1.9)
  GG 102 (25.6) 80 (21.5) 1.3 (0.9–2.0)
CCND1 GG 104 (26.1) 114 (30.6) 1.0. -
Pro241Pro AG 203 (51.0) 178 (47.8) 1.3 (0.9–1.9)
  AA 91 (22.9) 80 (21.5) 1.3 (0.9–1.8)
IL13 GG 240 (60.3) 252 (67.8) 1.0. -
Arg130Gln AG 144 (36.2) 105 (28.2) 0.8 (0.4–1.8)
  AA 14 (3.5) 15 (4.0) 1.2 (0.9–1.6)
IL1A GG 204 (51.3) 179 (48.1) 1.0. -
Ala114Ser GT 155 (38.9) 164 (44.1) 1.0 (0.7–1.3)
  TT 39 (9.8) 29 (7.8) 1.7 (1.0–2.8)
G-CSF AA 146 (36.7) 138 (37.1) 1.0. -
Leu185Leu AG 193 (48.5) 182 (48.9) 1.0 (0.7–1.3)
  GG 59 (14.8) 52 (14.0) 1.1 (0.7–1.8)
ESR1 TT 107 (26.9) 97 (26.1) 1.0. -
Ser10Ser CT 200 (50.3) 187 (50.3) 1.1 (0.7–1.6)
  CC 91 (22.9) 88 (23.7) 1.1 (0.7–1.4)
TNF-A GG 274 (68.8) 237 (63.7) 1.0. -
G(-308)A AG 113 (28.4) 120 (32.2) 0.9 (0.4–2.1)
  AA 11 (2.8) 15 (4.0) 0.9 (0.7–1.2)
CYP17 TT 170 (42.7) 172 (46.2) 1.0. -
C(518)T CC 60 (15.1) 49 (13.2) 1.5 (1.0–2.4)
  CT 168 (42.2) 151 (40.6) 1.3 (0.9–1.7)
BARD1 CC 174 (43.7) 142 (38.2) 1.0. -
Pro24Ser CT 188 (47.2) 184 (49.5) 0.8 (0.6–1.1)
  TT 36 (9.0) 46 (12.4) 0.8 (0.5–1.2)
XPD AA 146 (36.7) 165 (44.3) 1.0. -
Lys751Gln AC 194 (48.7) 167 (44.9) 1.3 (0.9–1.7)
  CC 58 (14.6) 40 (10.8) 1.6 (1.0–2.6)
IL10 AA 90 (22.6) 107 (28.7) 1.0. -
G(-1082)A AG 205 (51.5) 194 (52.2) 1.1 (0.7–1.5)
  GG 103 (25.9) 71 (19.1) 1.1 (0.7–1.6)
ESR1 CC 243 (61.1) 213 (57.3) 1.0. -
Pro325Pro CG 126 (31.7) 138 (37.1) 1.0 (0.7–1.3)
  GG 29 (7.3) 21 (5.6) 1.0 (0.5–1.8)
MTHFR CC 162 (40.7) 160 (43.0) 1.0. -
Ala222Val CT 170 (42.7) 161 (43.3) 1.1 (0.8–1.5)
  TT 66 (16.6) 51 (13.7) 1.3 (0.8–2.0)
GSTP1 AA 208 (52.3) 175 (47.0) 1.0. -
Ile105Val AG 149 (37.4) 161 (43.3) 1.1 (0.8–1.5)
  GG 41 (10.3) 36 (9.7) 1.3 (0.8–2.0)
GADD45 TT 189 (47.5) 177 (47.6) 1.0. -
C(IVS3+168)T CC 32 (8.0) 43 (11.6) 0.8 (0.5–1.3)
  CT 177 (44.5) 152 (40.9) 0.9 (0.7–1.2)
P27 TT 256 (64.3) 235 (63.2) 1.0. -
Val109Gly GG 17 (4.3) 15 (4.0) 1.0 (0.5–2.0)
  GT 125 (31.4) 122 (32.8) 1.0 (0.7–1.3)
MMP1 Del/del 110 (27.6) 104 (28.0) 1.0. -
1G(-1607)2G Ins/ins 92 (23.1) 94 (22.6) 0.8 (0.6–1.3)
  Ins/del 196 (49.2) 184 (49.5) 1.0 (0.7–1.4)
PTEN Del/del 171 (43.0) 196 (52.7) 1.0. -
(IVS4+109) ins/delACTAA Ins/ins 47 (11.8) 38 (10.2) 1.3 (0.8–2.1)
  Ins/del 180 (45.2) 138 (37.1) 1.2 (0.9–1.7)
GSTM3 Ins/ins 271 (68.1) 272 (73.1) 1.0. -
4595 (3bp ins/del) Del/del 7 (1.8) 9 (2.4) 0.9 (0.4–2.1)
  Ins/del 120 (30.1) 91 (24.5) 0.9 (0.7–1.3)
  1. *Age-adjusted odds ratios from unconditional logistic regression analyses.