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Table 8 Relative expression of mRNA levels in tumor samples after ex vivo exposure to cisplatin. The IC50 concentrations for the samples tested are shown for each drug (median and range). The p values have been calculated using non-parametric statistics, in detail the Wilcoxon matched pairs test. On statistical advice, we chose not to use a Bonferroni's correction, but it should be noted that some technically statistically significant results could have arisen by chance.

From: Cancer cell adaptation to chemotherapy

 

Breast samples IC50 = 18.4 μM (8.9–30.9)

Ovarian samples IC50 = 17.8 μM (6.3–25.6)

Target gene

n

Control

Cisplatin

p

n

Control

Cisplatin

p

ATP7B

13

0.256

0.177

0.0327

7

0.268

0.111

0.4375

ERCC1

13

0.933

1.382

0.0266

7

0.542

0.758

0.0156

MGMT

13

1.203

1.275

0.8926

7

0.794

0.944

0.1094

MLH1

13

0.758

1.000

0.1465

7

0.512

0.683

0.3750

MSH2

13

1.289

1.047

0.0479

7

2.579

2.732

0.9375

MSH6

13

2.351

2.194

0.1909

7

2.997

2.194

0.1094

MTII

13

44.221

53.817

0.5417

7

12.996

11.445

0.8125