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Table 8 Relative expression of mRNA levels in tumor samples after ex vivo exposure to cisplatin. The IC50 concentrations for the samples tested are shown for each drug (median and range). The p values have been calculated using non-parametric statistics, in detail the Wilcoxon matched pairs test. On statistical advice, we chose not to use a Bonferroni's correction, but it should be noted that some technically statistically significant results could have arisen by chance.

From: Cancer cell adaptation to chemotherapy

  Breast samples IC50 = 18.4 μM (8.9–30.9) Ovarian samples IC50 = 17.8 μM (6.3–25.6)
Target gene n Control Cisplatin p n Control Cisplatin p
ATP7B 13 0.256 0.177 0.0327 7 0.268 0.111 0.4375
ERCC1 13 0.933 1.382 0.0266 7 0.542 0.758 0.0156
MGMT 13 1.203 1.275 0.8926 7 0.794 0.944 0.1094
MLH1 13 0.758 1.000 0.1465 7 0.512 0.683 0.3750
MSH2 13 1.289 1.047 0.0479 7 2.579 2.732 0.9375
MSH6 13 2.351 2.194 0.1909 7 2.997 2.194 0.1094
MTII 13 44.221 53.817 0.5417 7 12.996 11.445 0.8125
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