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Table 7 Relative expression of mRNA levels in tumor samples after ex vivo exposure to 5 FU. The IC50 concentrations for the samples tested are shown for each drug (median and range). The p values have been calculated using non-parametric statistics, in detail the Wilcoxon matched pairs test. On statistical advice, we chose not to use a Bonferroni's correction, but it should be noted that some technically statistically significant results could have arisen by chance.

From: Cancer cell adaptation to chemotherapy

 

Breast samples IC50 = 200 μM (86.5–363)

Colorectal samples IC50 = 112 μM (13.8–311)

Target gene

n

Control

5-FU

p

n

Control

5-FU

p

DPD

13

1.289

0.494

0.0012

10

0.503

0.448

0.4922

TP

13

8.876

10.928

0.6848

10

4.616

5.963

0.084

TS

13

1.136

3.819

0.0005

10

2.157

7.954

0.002