Skip to main content

Table 7 Relative expression of mRNA levels in tumor samples after ex vivo exposure to 5 FU. The IC50 concentrations for the samples tested are shown for each drug (median and range). The p values have been calculated using non-parametric statistics, in detail the Wilcoxon matched pairs test. On statistical advice, we chose not to use a Bonferroni's correction, but it should be noted that some technically statistically significant results could have arisen by chance.

From: Cancer cell adaptation to chemotherapy

  Breast samples IC50 = 200 μM (86.5–363) Colorectal samples IC50 = 112 μM (13.8–311)
Target gene n Control 5-FU p n Control 5-FU p
DPD 13 1.289 0.494 0.0012 10 0.503 0.448 0.4922
TP 13 8.876 10.928 0.6848 10 4.616 5.963 0.084
TS 13 1.136 3.819 0.0005 10 2.157 7.954 0.002