Table 3 Relative expression of mRNA levels in esophageal samples obtained from patients before and after chemotherapy (median values). The last 2 columns on the right represent values for the 12 paired biopsies. The p values have been calculated using non parametric statistics, and in detail the Mann Whitney U test for unpaired samples, and the Wilcoxon matched pairs test for paired samples.
| Â | All esophageal samples | Â | Paired esophageal samples | Â | ||
|---|---|---|---|---|---|---|
Target gene | Pre-chemo n = 13 | Post-chemo n = 6 | p | Pre-chemo n = 6 | Post-chemo n = 6 | p |
DPD | 0.71 | 1.09 | 0.4117 | 0.68 | 1.09 | 0.3750 |
GST-Ï€ | 4.39 | 0.88 | 0.1969 | 1.61 | 1.85 | 0.8438 |
MDR1 | 0.07 | 0.37 | <0.0001 | 0.11 | 0.43 | 0.0313 |
MRP1 | 4.81 | 10.60 | 0.1624 | 4.58 | 10.77 | 0.4375 |
MT II | 36.35 | 23.43 | 0.5846 | 12.49 | 24.12 | 0.8438 |
MVP | 6.61 | 8.57 | 0.6544 | 6.39 | 9.11 | 0.5625 |
TP | 4.21 | 2.58 | 0.2326 | 3.56 | 3.01 | >0.999 |
TS | 1.11 | 2.43 | 0.1851 | 1.27 | 2.27 | 0.4375 |