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Archived Comments for: Familial breast cancer: characteristics and outcome of BRCA 1–2 positive and negative cases

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  1. There is another clinical, and overlooked tool, reliable in breast cancer prognosis evaluation.

    Sergio Stagnaro, Researcher in Biophysical Semeiotics

    6 July 2005

    The evaluation of breast cancer "possible" prognosis by means of studying BRCA mutations, such as BRCA positive and BRCA wild type (WT), is not applicable on very large scale, not to speak of womens involved by breast cancer without BRCA mutation but positive for MRY proteine! It is to say that today's doctors must know, in my opinion, the paramount developments of physical semeiotics occured over the last five decades, particularly as breast cancer clinical diagnosis, prognosis, as well as primary prevention is concerned (1,2,3). In fact, biophysical-semeiotic evluation of breast microcirculation allows doctor to assess local modifications, carachteristic of all malignancy stages, starting from breast cancer "real risk", clearly ignored by the authors (2,3,4,5). In other words, I think that the authors are unacquainted with the existence of a congenital acidosic functional mitochondrial cytopathology, "conditio sine qua non" of the most frequent and dangerous human disorders, including malignancies (3). That is, in a few words,they do not know the existence and, consequently, they can not assess precisely the seriousness as well as the precise location of Congenital Acidosic Enzyme-Metabolic Histangiopathy, and Oncological Terrain-dependent breast cancer "real risk" is based on (See also the website For instance, as regards breast cancer PRIMARY Prevention (1,2,3), we have to consider the importance of the genetic predisposition, now-a-days fortunately evaluated at the bed-side in a reliable way(See “Biophysical Constitutions” in the above-cited site), as far as the onset of a large number of disorders is concerned, including solid as well as liquid malignancies. Really, as allows to state a 48-year-long clinical experience, without this remarkable functional abnormality of psycho-neuro-endocrine-immunological system,i.e., Oncological Terrain, oncogenesis is not possible at all.

    As a consequence, in oncological medicine, the importance of the above-mentioned congenital mitochondrial cytopatology, inherited by MOTHER, should not be overlooked by physicians, particularly when we assess either a "possible" risk factor, e.g., for breast cancer,or it prognosis.

    1) Sergio Stagnaro. Bed-Side Prostate Cancer Detecting, even in early stages (“Real Risk” of Cancer): BMC Family Practice, 2005, 6:24 doi:10.1186/1471-2296-6-24 .

    2) Stagnaro-Neri M., Stagnaro S., Cancro della mammella: prevenzione primaria e diagnosi precoce con la percussione ascoltata. Gazz. Med. It. – Arch. Sc. Med. 152, 447, 1993

    3) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004.

    4)Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica condizione necessaria non sufficiente della oncogenesi. XI Congr. Naz. Soc. It. di Microangiologia e Microcircolaz. Abstracts, pg 38, 28 Settembre-1 Ottobre, 1983, Bellagio.

    5) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Una Patologia Mitocondriale Ignorata. Gazz Med. It. – Arch. Sci. Med. 144, 423, 1985 (Infotrieve).

    Competing interests

    None declared