Skip to main content

Advertisement

Table 1 Genes upregulated in all adenomas compared to normal mucosa (p < 0.05).

From: Differential gene expression profile reveals deregulation of pregnancy specific β1 glycoprotein 9 early during colorectal carcinogenesis

Name Description Gene ID Fold change
PSG9 pregnancy specific beta-1-glycoprotein 9 196828 2.59
PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform 469697 1.71
ITGA1 integrin, alpha 1 212078 1.95
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 220392 1.74
ALAS2 aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) 201112 1.98
DCN decorin 197609 1.85
JAG1 jagged 1 (Alagille syndrome) 117734 2.21
DPP6 dipeptidylpeptidase 6 166550 1.86
RNASE4 ribonuclease, RNase A family, 4 201596 2.44
XBP1 X-box binding protein 1 213933 1.95
CDC42 cell division cycle 42 (GTP binding protein, 25 kDa) 214563 1.73
MGC8407 hypothetical protein MGC8407 179857 1.78
NUP98 nucleoporin 98 kDa 206345 2.02
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 470149 1.56
IL1R2 interleukin 1 receptor, type II 470402 1.54
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 211877 1.64
TAGLN2 transgelin 2 152371 1.67
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor 365930 1.81
RAB25 RAB25, member RAS oncogene family 149515 1.64
ANAPC7 anaphase-promoting complex subunit 7 487822 1.79
MTCH2 mitochondrial carrier homolog 2 (C. elegans) 138486 1.8
HCA112 hepatocellular carcinoma-associated antigen 112 207556 2.3
BS69 adenovirus 5 E1A binding protein 31337 1.69
MGC29898 hypothetical protein MGC29898 504671 1.65
LOC124245 hypothetical protein BC001584 194780 2.05
FVT1 follicular lymphoma variant translocation 1 115784 1.55
FLJ20202 FLJ20202 protein 142952 1.59
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 32555 1.63
HEAB ATP/GTP-binding protein 212684 1.59
VRK3 vaccinia related kinase 3 488478 1.49
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 200735 1.48
WFDC2 WAP four-disulfide core domain 2 366323 1.85
KIAA0241 KIAA0241 protein 212216 1.83
GPR161 G protein-coupled receptor 161 489796 1.81
SLAMF8 SLAM family member 8 128371 1.99
ARG99 ARG99 protein 163160 1.7
LOC170394 hypothetical protein BC011630 154928 1.9
  1. Differentially expressed genes identified in adenomas compared to corresponding normal tissue. In total, 84 genes showed significant differential expression in all three adenomas compared to normal-appearing epithelial cells (p < 0.05). Thirty-seven genes were up-regulated (Table 1), and 47 down-regulated (Table 2). PSG9 showed a consistent 2-fold over-expression in all adenomas compared to normal mucosa (p < 0.006).