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Table 1 Genes upregulated in all adenomas compared to normal mucosa (p < 0.05).

From: Differential gene expression profile reveals deregulation of pregnancy specific β1 glycoprotein 9 early during colorectal carcinogenesis

Name

Description

Gene ID

Fold change

PSG9

pregnancy specific beta-1-glycoprotein 9

196828

2.59

PPP2CB

protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform

469697

1.71

ITGA1

integrin, alpha 1

212078

1.95

NEDD8

neural precursor cell expressed, developmentally down-regulated 8

220392

1.74

ALAS2

aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)

201112

1.98

DCN

decorin

197609

1.85

JAG1

jagged 1 (Alagille syndrome)

117734

2.21

DPP6

dipeptidylpeptidase 6

166550

1.86

RNASE4

ribonuclease, RNase A family, 4

201596

2.44

XBP1

X-box binding protein 1

213933

1.95

CDC42

cell division cycle 42 (GTP binding protein, 25 kDa)

214563

1.73

MGC8407

hypothetical protein MGC8407

179857

1.78

NUP98

nucleoporin 98 kDa

206345

2.02

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

470149

1.56

IL1R2

interleukin 1 receptor, type II

470402

1.54

PIP5K1B

phosphatidylinositol-4-phosphate 5-kinase, type I, beta

211877

1.64

TAGLN2

transgelin 2

152371

1.67

TAF7

TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor

365930

1.81

RAB25

RAB25, member RAS oncogene family

149515

1.64

ANAPC7

anaphase-promoting complex subunit 7

487822

1.79

MTCH2

mitochondrial carrier homolog 2 (C. elegans)

138486

1.8

HCA112

hepatocellular carcinoma-associated antigen 112

207556

2.3

BS69

adenovirus 5 E1A binding protein

31337

1.69

MGC29898

hypothetical protein MGC29898

504671

1.65

LOC124245

hypothetical protein BC001584

194780

2.05

FVT1

follicular lymphoma variant translocation 1

115784

1.55

FLJ20202

FLJ20202 protein

142952

1.59

ARHGDIA

Rho GDP dissociation inhibitor (GDI) alpha

32555

1.63

HEAB

ATP/GTP-binding protein

212684

1.59

VRK3

vaccinia related kinase 3

488478

1.49

HLA-DPA1

major histocompatibility complex, class II, DP alpha 1

200735

1.48

WFDC2

WAP four-disulfide core domain 2

366323

1.85

KIAA0241

KIAA0241 protein

212216

1.83

GPR161

G protein-coupled receptor 161

489796

1.81

SLAMF8

SLAM family member 8

128371

1.99

ARG99

ARG99 protein

163160

1.7

LOC170394

hypothetical protein BC011630

154928

1.9

  1. Differentially expressed genes identified in adenomas compared to corresponding normal tissue. In total, 84 genes showed significant differential expression in all three adenomas compared to normal-appearing epithelial cells (p < 0.05). Thirty-seven genes were up-regulated (Table 1), and 47 down-regulated (Table 2). PSG9 showed a consistent 2-fold over-expression in all adenomas compared to normal mucosa (p < 0.006).
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BMC Cancer

ISSN: 1471-2407

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