Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice

Table 1 Tumor regression following intratumoral injection of Ad.p35 plus Ad.p40, or Ad.CD/5-FC alone, or a combination of both

Treatment	Response (%)
	N	Complete	Partial	Death or peritoneal metastasis	None
Ad.p35 + Ad.p40 + Ad.CD/5-FC	15	4 (27)	4 (27)	0 (0)	7 (46)
Ad.p35 + Ad.p40	15	1 (7)	2 (14)	‡2 (13)	10 (66)
Ad.CD/5-FC	15	1 (7)	0 (0)	†1 (7)	13 (86)
Ad.GFP	15	0 (0)	0 (0)	†1 (7)	14 (93)

N = number of Renca tumor-bearing mice injected once intratumorally with adenoviral vectors at the doses indicated in Figure 4 legend.
"Complete" refers to animals undergoing total and permanent regression of the injected tumor.
"Partial" refers to animals undergoing partial tumor regression followed by regrowth, or a significant delay in growth
"Death or peritoneal metastasis" refers to animals that died or had peritoneal metastasis during the period of investigation.
None refers to animals whose tumors have continued to grow at a rate comparable to controls.
†Death probably by toxicity.
‡Excluded due to peritoneal metastasis during the experiment.

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