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Table 2 Summary of MMR studies in UUC

From: Low frequency of defective mismatch repair in a population-based series of upper urothelial carcinoma

Reference Sex (male: female) Median age total/MSI-H Total no. of patients (renal pelvis/ureter/multifocal) Fraction MSI-high IHC loss
Hartmann et al. 2.2:1 66 / 62 73 (40/22/11) 0.21 0.87
Catto et al. 2.0:1 68 / 66 71 (44/25/2) 0.13 0.78
Blaszyk et al. 2.8:1 70 / - 114 (61/53/-) 0.31 ND
Roupert et al. 3.4:1# - / 70 164 (ND) 0.16 0.6*
Amira et al. 1.6:1 68 / 72 24 (19/4/1) 0.25 ND
Ericson et al. 1.8:1 67 / 67 216 (154/60/2) 0.04 0.78
  1. * Only MSH2 assessed, ND: not determined
  2. #Applies to subset with MSI