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Table 3 3H-proline incorporation into collagen fibres

From: Human desmoid fibroblasts: matrix metalloproteinases, their inhibitors and modulation by Toremifene

  Cells Media Cells + Media
  48 h
Desmoid fibroblasts 6,852 ± 290 33,915 ± 2,307 40,767
Desmoid fibroblasts + toremifene 4,243 ± 361* 25,097 ± 814* 29,340
  24 h
Desmoid fibroblasts 4,252 ± 416 15,423 ± 1,100 19,675
Desmoid fibroblasts + toremifene 1,432 ± 101* 9,221 ± 381* 10,653
  3 h
Desmoid fibroblasts 1,176 ± 48 1,498 ± 56 2,674
Desmoid fibroblasts + toremifene 534 ± 31* 745 ± 74* 1,279
  1. Fibroblasts were cultured for 48 h in MEM with or without toremifene. 3H-proline was added for 48 h, for the last 24 h and for the last 3 h. Total radioactivity value is expressed in cpm/mg protein and represents the mean ± SD of three determinations, each in quadruplicate. The statistical analysis was performed with analysis of variance (ANOVA). Differences vs desmoid fibroblasts: F-test significant at *99%.