Table 3 Immune response and interferon signalling
Gene Symbol (Probe) | Function/family | †Fold change (qRT-PCR) | Rank | Function/Other information |
|---|---|---|---|---|
APP | Amyloid precursor protein | 1.6 (ND) | 21 | Proinflammatory |
HLA-DRB1 | Histocompatability complex, class II, DR beta 1 | -1.3 (ND) | 89 | Signal transduction; antigen processing |
IFI27 | Interferon (IFN)-alpha inducible Protein 27 | -1.3 (-1.9) | 81 | Integral membrane protein; unknown function |
IFIT1 | IFN-induced protein with tetratricopeptide repeats | 1.4 (1.3) | 47 | Transmembrane protein; Interferon, retinoic acid inducible |
IFITM1 | IFN-induced transmembrane protein 1 | 1.5 (2.9) | 28 | Growth inhibition |
PTMA/TMSA | Prothymosin A | -1.4 (ND) | 53 | Innate immunity; nuclear; associated with proliferation |
RIG-I/DDX58 | Retinoic acid inducible gene I/DEAD box 58 | 1.3 (1.7) | 79 | IFN signalling; RNA helicase |
TRA1/GP96 | Tumor rejection antigen 1 | 1.3 (NC) | 98 | Glycoprotein; stress response |
USP18/UBP 43 | Ubiquitin specific protease 18 | -1.5 (-1.6) | 35 | Protease/ubiquitinase regulated by IFN |