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Table 3 Immune response and interferon signalling

From: Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells

Gene Symbol (Probe) Function/family †Fold change (qRT-PCR) Rank Function/Other information
APP Amyloid precursor protein 1.6 (ND) 21 Proinflammatory
HLA-DRB1 Histocompatability complex, class II, DR beta 1 -1.3 (ND) 89 Signal transduction; antigen processing
IFI27 Interferon (IFN)-alpha inducible Protein 27 -1.3 (-1.9) 81 Integral membrane protein; unknown function
IFIT1 IFN-induced protein with tetratricopeptide repeats 1.4 (1.3) 47 Transmembrane protein; Interferon, retinoic acid inducible
IFITM1 IFN-induced transmembrane protein 1 1.5 (2.9) 28 Growth inhibition
PTMA/TMSA Prothymosin A -1.4 (ND) 53 Innate immunity; nuclear; associated with proliferation
RIG-I/DDX58 Retinoic acid inducible gene I/DEAD box 58 1.3 (1.7) 79 IFN signalling; RNA helicase
TRA1/GP96 Tumor rejection antigen 1 1.3 (NC) 98 Glycoprotein; stress response
USP18/UBP 43 Ubiquitin specific protease 18 -1.5 (-1.6) 35 Protease/ubiquitinase regulated by IFN
  1. † "Fold change," top number is the relative expression of RARβ2 transduced cells/empty vector control cells from Agilent arrays. The number in parentheses is the relative expression of the same cells from qRT-PCR analysis, normalized by respective qRT-PCR RPLP0 expression.
  2. ND = not done
  3. NC = differential expression was not confirmed by qRT-PCR, and this gene has mRNA isoform that overlaps the 60-mer probe