Figure 3

Model of antimetastatic functions modulated by RARβ2. Expression of RARβ2 in metastatic breast cancer cells confers multiple antimetastatic properties, including induction of cancer antigens, tumor suppressors, and genes involved in interferon signalling. Other gene activities are suppressed through RARβ2 action: AP1, cell adhesion, and nutrient processes. All gene activities in this diagram have been confirmed by cell culture qRT-PCR. Gene names in italics (red), have also been confirmed using randomly selected xenograft primary tumors, comparing two pairs of vector control- and RARβ2-resected tumors.