Table 1 Patient characteristics
| Â | Sporadic cases | BRCA1 carriers | ||
|---|---|---|---|---|
| Â | Â | All familial cases | 1135insA | 1675delA |
No of cases | 100 | 30 | 10 | 20 |
Age at diagnosis: Median | 59 | 49 | 52.5 | 47 |
range | 39 – 80 | 39 – 80 | 41 – 80 | 39 – 65 |
FIGO stage | Â | Â | Â | Â |
I – II | 9 (9.0%) | 8 (26.7%) | 2 (20.0%) | 6 (30.0%) |
III | 65 (65.0%) | 14 (46.7%) | 5 (50.0%) | 9 (45.0%) |
IV | 26 (26.0%) | 8 (26.7%) | 3 (30.0%) | 5 (25.0%) |
Histology | Â | Â | Â | Â |
Serous | 82 (82.0%) | 24 (80.0%) | 7 (70.0%) | 17 (85.0%) |
Mixed | 7 (7.0%) | 2 (6.6%) | 1 (10.0%) | 1 (5.0%) |
Endometroid | 5 (5.0%) | 3 (10.0%) | 1 (10.0%) | 2 (10.0%) |
Unclassified | 6 (6.0%) | 1 (3.3%) | 1 (10.0%) | 0 |
Grade of differentiation | Â | Â | Â | Â |
1 | 7 (7.0%) | 0 | 0 | 0 |
2 | 26 (26.0%) | 5 (16.6%) | 1 (10.0%) | 4 (20.0%) |
3 | 67 (67.0%) | 24 (80.0%) | 9 (90.0%) | 15 (75.0%) |
Unknown | 0 | 1 (3.3%) | 0 | 1 (5.0%) |
Survival >5 years | 23 (23.0%) | 10 (33.3%) | 3 (30.0%) | 7 (35.0%) |
TP53 mutation status | 72.0% | 53.3% | 50.0% | 55.0% |