Randomized phase II – study evaluating EGFR targeting therapy with Cetuximab in combination with radiotherapy and chemotherapy for patients with locally advanced pancreatic cancer – PARC: study protocol [ISRCTN56652283]

Table 2 Table 1

Investigation	Pretreatment	Chemoradiation / Chemotherapy weekly	Each Course of Infusional Gemcitabine/ Cetuximab	follow-up
Clinical examination	X	X	X	X
Laboratory tests	X^a	X	X	X
Tumor markers	X^b	X	X	X
CT Abdomen	X			X^c
CXR, PA, LAT	X		X	X
Renal function	X^d
Pregnancy Test ^f	X
SAE	X	X	X
QOL Survey	X^e	X	X	X

a. Includes Electrolytes, BUN, Creatinine, SGOT, Alk Phos, Total Bilirubin, Albumin, Glucose, Calcium, auto-antibodies
b. Includes CEA and CA 19-9
c. A CT scan will be performed 4 weeks after chemoradiation and than every 3 months.
d. Includes CT with i.v. contrast
e. QLQ-C30, QLQ-Pan 26
f. If indicated

ISSN: 1471-2407