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Figure 2 | BMC Cancer

Figure 2

From: Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts

Figure 2

Results of clonogenic assay of breast cancer cells co-cultured with fibroblasts in the presence or absence of heparin and/or FGF-7. After 14 days of co-culture, the numbers of colonies containing 10 or more tumor cells were counted and averaged. Heparin significantly reduced the numbers of tumor cell colonies in the presence or absence of exogenous FGF-7. When the tumor cells were cultured in the absence of fibroblasts, only an average of 24 colonies were formed, and the heparin had no significant effect on the numbers of colonies.

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