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Figure 1 | BMC Cancer

Figure 1

From: Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts

Figure 1

Representative photomicrographs of mast cell infiltration in human head and neck cancer (1a), lung cancer (1b, c), ovarian cancer (1d, e), and Hodgkin's disease (1f). In Figures a-c, e and f, the sections were immunostained for mast cell tryptase and revealed extensive evidence of mast cell degranulation (brown stain) in the fibrous tissue adjacent to nests of tumor cells and blood vessels. A Giemsa stain (1d) confirmed the presence of intact mast cells with dense purple granules embedded within fibrous stroma between nests of tumor cells. Hematoxylin counterstain (all figures, except 1d).

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