Ref. | Regimen | Oxaliplatin Dose: mg/m2 | Planned Oxaliplatin Dose intensity: mg/m2/wk | Treatment | ≥ grade 3 |
---|---|---|---|---|---|
25 | OX + FU/LVa chronotherapy | Both arms: 20 days 1–5 q 3 wk 20/10.5 hr CI; peak at 4:00 pm | 33.3 | First line | 16% |
 | Constant rate | 20/24 hr CI |  |  | 31% |
26 | OX + FU/LVb | 125/6 hr day 1 q 3 wk 10:00 am to 4:00 pm | 41.7 | First line | 10% |
3 | FOLFOX 4 | 85/2 hr day 1 q 2 wk | 42.5 | First line | 18.2% |
4 | FOLFOX 4 | 85/2 hr day 1 q 2 wk | 42.5 | First line | 18% |
 | IROX | 85/1.5 hr day 1 q 3 wk | 28.3 |  | 7% |
5 | FOLFOX 6 | 100/2 hr day 1 q 2 wk | 50 | First line | 34% |
27 | FUFOX | 50/2 hr days 1, 8, 15, 22 q 5 wkc | 40 | First line | 17% |
28 | FUFOX | 50/x hr days 1, 8, 15, 22 q 5 wkc | 40 | First line | 25% |
 | CAPOX | 70/x hr d 1, 8 q 3 wk | 46.7 |  | 16% |
17 | FOLFOX 4 | 85/2 hr day 1 q 2 wk | 42.5 | Adjuvant | 12% |
5 | FOLFOX 6 | 100/2 hr day 1 q 2 wk | 50 | Second lined | 20% |
29 | FOLFOX 4 | 85/2 hr day 1 q 2 wk | 42.5 | Second or third linee | 3%f |