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Table 2 Tumor to non-tumor tissue ratios of antibody concentrations

From: Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers

  24 h 72 h
Tissue VG-IgG2κ X4        VG-IgG2κ X4
Liver 8.63 ± 0.30a 10.98 ± 0.35 13.41 ± 0.41 15.80 ± 0.41
Kidneys 9.00 ± 0.30 7.13 ± 0.37 14.14 ± 0.42 10.33 ± 0.43
Lungs 4.23 ± 0.32 5.13 ± 0.36 6.03 ± 0.40 6.74 ± 0.41
Spleen 13.32 ± 0.33 13.48 ± 0.37 16.54 ± 0.42 17.53 ± 0.42
Heart 6.00 ± 0.30 7.34 ± 0.34 8.80 ± 0.41 10.00 ± 0.43
Muscle 28.30 ± 0.31 28.78 ± 0.36 36.48 ± 0.44 36.18 ± 0.45
Bone 31.15 ± 0.64 24.50 ± 0.68 26.14 ± 0.43 23.95 ± 0.42
Skin 5.74 ± 0.29 7.01 ± 0.33 9.10 ± 0.42 10.05 ± 0.43
Stomach 19.13 ± 0.31 12.64 ± 0.38 59.76 ± 0.46 40.04 ± 0.49
Small bowel 23.73 ± 0.30 26.12 ± 0.34 37.84 ± 0.42 41.97 ± 0.43
Large bowel 33.92 ± 0.29 33.57 ± 0.35 67.68 ± 0.42 68.45 ± 0.45
Carcass 10.39 ± 0.30 12.39 ± 0.34 15.39 ± 0.40 17.22 ± 0.42
Blood 1.74 ± 0.32 2.24 ± 0.38 2.81 ± 0.41 3.15 ± 0.42
  1. aRatios were calculated by dividing the %ID/g of the tumor by that obtained in each individual organ.