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Table 2 Tumor to non-tumor tissue ratios of antibody concentrations

From: Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers

 

24 h

72 h

Tissue

VG-IgG2κ

X4       

VG-IgG2κ

X4

Liver

8.63 ± 0.30a

10.98 ± 0.35

13.41 ± 0.41

15.80 ± 0.41

Kidneys

9.00 ± 0.30

7.13 ± 0.37

14.14 ± 0.42

10.33 ± 0.43

Lungs

4.23 ± 0.32

5.13 ± 0.36

6.03 ± 0.40

6.74 ± 0.41

Spleen

13.32 ± 0.33

13.48 ± 0.37

16.54 ± 0.42

17.53 ± 0.42

Heart

6.00 ± 0.30

7.34 ± 0.34

8.80 ± 0.41

10.00 ± 0.43

Muscle

28.30 ± 0.31

28.78 ± 0.36

36.48 ± 0.44

36.18 ± 0.45

Bone

31.15 ± 0.64

24.50 ± 0.68

26.14 ± 0.43

23.95 ± 0.42

Skin

5.74 ± 0.29

7.01 ± 0.33

9.10 ± 0.42

10.05 ± 0.43

Stomach

19.13 ± 0.31

12.64 ± 0.38

59.76 ± 0.46

40.04 ± 0.49

Small bowel

23.73 ± 0.30

26.12 ± 0.34

37.84 ± 0.42

41.97 ± 0.43

Large bowel

33.92 ± 0.29

33.57 ± 0.35

67.68 ± 0.42

68.45 ± 0.45

Carcass

10.39 ± 0.30

12.39 ± 0.34

15.39 ± 0.40

17.22 ± 0.42

Blood

1.74 ± 0.32

2.24 ± 0.38

2.81 ± 0.41

3.15 ± 0.42

  1. aRatios were calculated by dividing the %ID/g of the tumor by that obtained in each individual organ.