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Figure 4 | BMC Cancer

Figure 4

From: CD155/PVR plays a key role in cell motility during tumor cell invasion and migration

Figure 4

CD155 is recruited to the leading edge of migrating cells and colocalizes with actin and αv-integrin. (a) HT1080 cells were grown to near confluency on a matrigel substrate. A linear wound was made with a 20 g needle and cells allowed to recover for 3 h. Cells were fixed and immunostained for CD155. The majority of CD155 appeared to localize to the leading edge of migrating cells. (b) CD155 colocalized extensively with actin and αv-integrin at the leading edge of HT1080 cells migrating on a matrigel substrate. CD155 did not appear to colocalize with the growth-factor receptor ErbB2.

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