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Table 4 Genetic networks affected by tipifarnib

From: Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

Network Genes in Ingenuity network* Associated pathways Score†
1 CD226, CD24, CD36, CD63, CEBPD, CRKL, CSF2RB, CSK, DF, DOK1, FACL2, FCAR, FCER1G, FGFR1, GAB2, GP6, GRIN1, ICAM1, ICAM2, ICAM3, INPP5D, INSR, ITGAL, ITGB2, LAT, LYN, MAD2L1, NEDD9, PECAM1, PPARG, PTK2B, SORBS1, STAT5B, SYK, UCP2 Immunity Inflammation Apoptosis Cell death Adhesion 24
2 ABCB1, ADORA3, APOC3, AR, BRCA1, C20ORF14, CAV1, CCNA1, CCNB1-RS1, CCND1, CDK2, CDKN2A, CDKN2D, CKS1B, CREM, E2F1, E2F4, ELA2, ESRRA, FGFR3, GNAQ, GNB1, GNG5, HDAC1, ICAM1, JUN, KLKB1, LAMP1, MKI67, PLCB2, PTPN2, PTPN9, RB1, RBBP2, TTK Cell cycle Transcription Apoptosis 20
3 ABCB1B, ARL6IP, BAX, BCL2, CAPN1, CDC25C, CDKN1A, CEBPE, CREM, CSF2RA, CSF3R, CTCF, EMP1, F2, FACL3, GPI, LTB4R, MAPK14, MARK3, MEF2A, MYC, MYCN, PIM1, PPP1R15A, PTGS2, RPL21, RPL6, RPS12, RPS16, RPS5, SERPIND1, SLC19A1, SP1, TP53, USF1 Cell cycle Cell death Proliferation 13
4 ANXA1, ANXA2, APOH, BCR (BREAKPOINT CLUSTER REGION), CD22, CD48, DOK2, EIF3S2, EIF3S6, EIF3S7, EPHA4, ERBB3, FGR, FN1, FYN, GRB2, HCLS1, IGF2R, IL6R, IL6ST, KRAS2, LCK, LIF, LY6, PLAU, PLAUR, PLG, RET, S100A10, SHC1, SLC11A1, ST14, TNC, TRPV4, ZFP106 Chemotaxis Proliferation Apoptosis 13
5 ACT1, APLP2, BIRC4, CAMKL, CASP3, CASP6, CASP8, CASP9, CCL20, DRPLA, EGR1, EIF4B, FKBP5, HNF4A, IFI30, LMNB1, LYZ, NR0B2, NR3C1, NUMA1, PCYT1A, PLEC1, PRKCZ, RELA, RELB, RIPK2, RPS6KA1, TAX1BP1, TNFRSF25, TNFRSF5, TRAF1, TRAF3, TRAF5, VIM, WEE1 Apoptosis Cell death Proliferation 11
  1. * Bold genes are those identified by the microarray analysis. Other genes were either not on the expression array or not significantly regulated. † A score of > 3 was considered significant (p < 0.001).