Table 4 Genetic networks affected by tipifarnib

1

CD226, CD24, CD36, CD63, CEBPD, CRKL, CSF2RB, CSK, DF, DOK1, FACL2, FCAR, FCER1G, FGFR1, GAB2, GP6, GRIN1, ICAM1, ICAM2, ICAM3, INPP5D, INSR, ITGAL, ITGB2, LAT, LYN, MAD2L1, NEDD9, PECAM1, PPARG, PTK2B, SORBS1, STAT5B, SYK, UCP2

Immunity Inflammation Apoptosis Cell death Adhesion

24

2

ABCB1, ADORA3, APOC3, AR, BRCA1, C20ORF14, CAV1, CCNA1, CCNB1-RS1, CCND1, CDK2, CDKN2A, CDKN2D, CKS1B, CREM, E2F1, E2F4, ELA2, ESRRA, FGFR3, GNAQ, GNB1, GNG5, HDAC1, ICAM1, JUN, KLKB1, LAMP1, MKI67, PLCB2, PTPN2, PTPN9, RB1, RBBP2, TTK

Cell cycle Transcription Apoptosis

20

3

ABCB1B, ARL6IP, BAX, BCL2, CAPN1, CDC25C, CDKN1A, CEBPE, CREM, CSF2RA, CSF3R, CTCF, EMP1, F2, FACL3, GPI, LTB4R, MAPK14, MARK3, MEF2A, MYC, MYCN, PIM1, PPP1R15A, PTGS2, RPL21, RPL6, RPS12, RPS16, RPS5, SERPIND1, SLC19A1, SP1, TP53, USF1

Cell cycle Cell death Proliferation

13

4

ANXA1, ANXA2, APOH, BCR (BREAKPOINT CLUSTER REGION), CD22, CD48, DOK2, EIF3S2, EIF3S6, EIF3S7, EPHA4, ERBB3, FGR, FN1, FYN, GRB2, HCLS1, IGF2R, IL6R, IL6ST, KRAS2, LCK, LIF, LY6, PLAU, PLAUR, PLG, RET, S100A10, SHC1, SLC11A1, ST14, TNC, TRPV4, ZFP106

Chemotaxis Proliferation Apoptosis

13

5

ACT1, APLP2, BIRC4, CAMKL, CASP3, CASP6, CASP8, CASP9, CCL20, DRPLA, EGR1, EIF4B, FKBP5, HNF4A, IFI30, LMNB1, LYZ, NR0B2, NR3C1, NUMA1, PCYT1A, PLEC1, PRKCZ, RELA, RELB, RIPK2, RPS6KA1, TAX1BP1, TNFRSF25, TNFRSF5, TRAF1, TRAF3, TRAF5, VIM, WEE1

Apoptosis Cell death Proliferation

11