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Table 2 Country of Ancestry Indices in Adult Whites in Central Alabama. *

From: Ancestry reported by white adults with cutaneous melanoma and control subjects in central Alabama

Country

Melanoma Probands

Control Subjects

p Value†

England

0.6559

0.7755

0.2896

Ireland

0.9573

0.6603

0.0150

Scotland

0.5924

0.3038

0.0031

Ireland + Scotland ("Celts")

1.5500

0.9640

0.0002

Wales

0

0.0674

(0.0005)

British Isles

2.2057

1.8069

0.0032

Native American

0.3184

0.2998

0.8493

Germany

0.4370

0.4610

0.8081

France

0.0889

0.1888

0.0001

Norway

0.0222

0.0230

0.9770

Netherlands

0.0903

0.1089

0.6909

Lithuania

0

0.0031

(0.9323)

Czechoslovakia

0.0037

0.0125

0.2967

Spain

0

0.0219

(0.0442)

Austria

0.0028

0.0214

0.0486

Belgium

0.0111

0.0031

0.4951

Denmark

0.0073

0.0167

0.3996

Finland

0

0.0063

(0.6110)

Greece

0.0203

0.0408

0.4491

Hungary

0.0222

0.0094

0.5863

Italy

0

0.1129

(0.0002)

Poland

0

0.0512

(0.0006)

Romania

0

0.0157

(0.3308)

Russia

0

0.0439

(0.0111)

Sicily

0

0.0392

(0.0667)

Sweden

0.0111

0.0674

0.0186

Switzerland

0

0.0157

(0.1400)

Europe Not British Isles

0.7169

1.2628

0.0001

North, Central, and South American Countries

0.1000

0.0533

0.4378

Near and Middle East Countries

0.0444

0.0408

0.9407

African Countries

0

0.0063

(0.6110)

Don't Know

0.5778

0.5235

0.6126

  1. * These data include all reports by each evaluable study participant. The questionnaire and interview reports from each participant were evaluated to yield individual country of ancestry scores which reflect proportional national ancestry. For this, each participant was assigned 4.00 points divided equally among each of his/her 4 grandparents. If a participant indicated 2 or more countries of ancestry for a grandparent, the 1.00 point for that grandparent was equally divided among the respective countries to formulate the scores of individual participants. We also computed aggregate country of ancestry indices for melanoma probands and control subjects as estimates of group ancestry composition. These indices were expressed as the quotient of total individual scores for respective countries and the total number of melanoma probands or control subjects, as appropriate. The category "British Isles" was defined as the reports in England, Ireland, Scotland, and Wales categories. The category "Europe not British Isles" is comprised of the composite data from the corresponding individual countries displayed in the present table. Participants who indicated specific "Native American" ancestry most frequently reported Cherokee and Creek descent. The "North, Central, and South America Countries" category (other than "Native Americans") included Canada, United States, Virgin Islands, Colombia, and Brazil. The category "Near and Middle East Countries" included reports about grandparents from Iran, Lebanon, and Syria. The single observation in "African Countries" represents the Republic of South Africa. The "Don't Know" categories include data from participants who reported this category for one, two, or three grandparents. † Student t test cannot be used to compare country of ancestry data groups in which all values were 0 (no variability). Accordingly, we arbitrarily assigned a country of ancestry datum of 0.25 for one person in each proband country group for which there were no actual country of ancestry reports. Student t test was then performed using this modified data group; estimated values of p from these tests are displayed in parentheses.
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BMC Cancer

ISSN: 1471-2407

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