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Table 3 Selected highly expressed genes in grade III and IV astrocytomas.

From: Identification of astrocytoma associated genes including cell surface markers

Tag Sequence Tumora Inductionb Gene Gene Ontology
    Anaplastic astrocytomas (Grade III)  
AAGCCGAAGA 10 40 GFAP glial fibrillary acidic protein Major intermediate filament protein of mature astrocytes
CTGGGGAGTG 8.1 22 VAPB VAMP associated protein B and C Type IV membrane protein in plasma and intracellular vesicle membranes
GCAACAGCAA 80.9 19 SEC61G Sec61 gamma subunit Endoplasmatic reticulum membrane protein, translocation
TTAATCTGAG 6.9 18 ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6, intra-cellular
ATCTTGTTAC 11 15 FN1 fibronectin 1 Extra-cellular matrix, cell adhesion, cell migration
GGAACAAACA 11.9 14 CD24 Plasma membrane, small cell lung carcinoma cluster 4 antigen
AGGGAGGGGC 32.9 14 GPX3 glutathione peroxidase 3 Extra-cellular, response to oxidative stress, glutathione metabolism
GTATGGGCCC 26.8 13 CHI3L1 chitinase 3-like 1 Cartilage glycoprotein
ACGAGGGGTG 71.4 12 BCAN, chondroitin sulfate proteoglycan Cell adhesion
CACTTGAAAA 6.9 11 CALU calumenin Endoplasmatic reticulum, calcium ion binding
GATAACTACA 6.7 11 IGFBP7 Extra-cellular, insulin-like growth factor binding protein 7
TCCTGTAAAG 6.8 11 CAV1 caveolin 1, 22 kDa Plasma membrane, caveolae protein, integrin-mediated celladhesion, vesicular trafficking
GTCTTAAAGT 41.8 10 SOD2 Superoxide dismutase, mitochondrial, erythropoietin-mediated neuro protection through NF-kB
    Glioblastomas (grade IV)  
GTATGGGCCC 144.2 72 CHI3L1 chitinase 3-like 1 Cartilage glycoprotein
GACCACCTTT 17.3 69 MFAP2 microfibrillar-associated protein 2 Major antigen of elastin-associated microfibrils
ACCAAAAACC 115.8 49 COL1A1 collagen, type I, alpha 1 Extra-cellular matrix
AGTGGTGGCT 14.8 39 FMOD fibromodulin Extra-cellular matrix, TGF beta receptor complex assembly
CTGGGGAGTG 13.2 35 VAPB VAMP associated protein B and C Type IV membrane protein in plasma and intracellular vesicle membranes
ACATTCTTTT 38.2 34 GPNMB glycoprotein nmb Transmembrane glycoprotein
ATCTTGTTAC 21.1 28 FN1 fibronectin 1 Extra-cellular matrix, cell adhesion, cell migration
GCAACAGCAA 97.9 23 SEC61G Sec61 gamma subunit Endoplasmatic reticulum membrane protein, translocation
TCACCAAAAA 19.3 19 STAB1 stabilin 1 Cell adhesion, calcium ion binding
CACTTGAAAA 11.6 19 CALU calumenin Endoplasmatic reticulum, calcium ion binding
TTTTCAAATA 15.4 15 T1A-2 lung type-I Type I integral membrane glycoprotein
GTCTTTCTTG 24.4 14 RAB13 Cell adhesion, member RAS oncogene family
GGAAATGTCA 12.6 13 MMP2 matrix metalloproteinase Extra-cellular matrix, calcium ion binding
GTACTAGTGT 23.8 12 CCL2 chemokine (C-C motif) ligand 2 Extra-cellular matrix, cell adhesion, signal transduction
AAGCTGTATA 16.7 12 TNC tenascin C (hexabrachion) Extra-cellular matrix, cell adhesion
GTGCTAAGCG 10.8 11 COL6A2 collagen, type VI, alpha 2 Extra-cellular matrix
CATATCATTA 151.6 11 IGFBP7 Extra-cellular, insulin-like growth factor binding protein 7
AACACAGCCT 24.9 11 C4A complement component 4A Extra-cellular matrix, complement pathway
  1. Highly expressed genes were selected with at least a ten fold over-expression when compared to normal neural tissue and a minimal expression level of at least 5 or 10 counts per 100,000 tags (in respectively grade III and IV tumors) in 30% of the corresponding tumor type. aAverage tag count count per individaul tunor SAGE library. bAverage induction factor.