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Table 3 Haematological toxicity of irinotecan combined with 5-FU 425 mg/m2 and FA 20 mg/m2 Mayo Clinic schedule (worst grade by patient)

From: Phase I/II study of first-line irinotecan combined with 5-fluorouracil and folinic acid Mayo Clinic schedule in patients with advanced colorectal cancer

Dose level Irinotecan (mg/m2) No. of patients Neutropenia grade Thrombocytopenia grade Anaemia grade Febrile neutropenia
     1 2 3 4 1 2 3 4 1 2 3 4  
Phase I I 250 6 0 1 1 4 2 0 1 0 2 3 0 0 1
  II 300 8 1 0 3 2 1 0 0 0 0 2 0 1 0
  Overall 14 1 (7%) 1 (7%) 4 (29%) 6 (43%) 3 (21%) 0 1 (7%) 0 2 (14%) 5 (36%) 0 1 (7%) 1 (7%)
Phase II 250 49 3 (6%) 6 (12%) 7 (14%) 31 (63%) 8 (16%) 1 (2%) 0 1 (2%) 11 (22%) 9 (18%) 2 (4%) 0 3 (6%)