Figure 3

Summary of LOH analysis and map information. A. Sequence maps of 1p markers and genes were obtained from NCBI gene maps and UniSTS records (updated as of September 2002). Salmon coloured horizontal lines delimit the smallest overlapping region flanked by D1S2713 and D1S2134 [6]. LOH results for 11 RAD54L polymorphism informative cases are taken from previous published and unpublished results (see the text). Open and closed circles correspond to retention and loss of heterozygosity respectively. The horizontal bar represents uninformative constitutional homozygosis. Patient identification as in ref. 5. B. SSCP of constitutive (C) and tumoral (T) DNA from patients 13 and 14, showing LOH of RAD54L and retention of heterozygosity for D1S197 and D1S232 markers.