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Table 6 Prostate

From: Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis

Author Cases n Controlsa/Cohortb Source population Exposure definition Exposure assessment Drug RR 95% CI
Nelson et al. [38] 417 420a Hospital based >1 tablet/day in the year prior to admission Personal Interview NSAIDs (15%) 0.34 0.20–0.58
Langman et al. [36] 1,813 5,354a Population based >7 prescriptions during months 13–36 before index date Automated Database NSAIDs (7%) 1.33 1.07–1.64
Norish et al. [39] 317 480a Population based >1 tablet/week Mailed Questionnaire Aspirin (29%) 0.85 0.61–1.19
       NA-NSAIDs (7%) 0.87 0.49–1.55
       NSAIDs (36%) 0.88 0.64–1.20
Irani et al. [53] 639 659a Hospital based Ever use In-hospital Questionnaire NA-NSAIDs (46%) 0.80 0.66–1.07
Neugut et al. [62] 319 189a Hospital based Chronic aspirin use Medical records Aspirin (7%) 1.60 0.82–3.11
Roberts et al. [41] 91 1,362b Cohort Daily use Mailed Questionnaire NSAIDs (42%) 0.37 0.22–0.62
Paganini-Hill et al. [40] 149 5,106b Cohort Daily use of aspirin for an undefined time Mailed Questionnaire Aspirin (17%) 0.94§ 0.61–1.44
Thun et al. [46] N.R. 290,681b Cohort More than 16 times per month for at least one year Mailed Questionnaire Aspirin (11%) 0.82 0.56–1.19
Schreinemachers et al. [43] 123 5,179b Cohort Ever use of aspirin in the 30 days prior to start date Personal Interview Aspirin (51%) 0.95 0.66–1.35
Leitzmann et al. [52] 2,479 47,882b Cohort ≥2 tablets per week reported in 4 consecutive questionnaires Mailed Questionnaire Aspirin (N.R.) 1.04 0.86–1.26
Habel et al. [57] 2,574 90,100b Cohort >6 tablets almost ever day In hospital Questionnaire Aspirin (2.7%) 0.76 0.60–0.98
  1. Prevalence of exposure among controls/cohort; §Crude estimate calculated from data provided in the original manuscript; Genital (includes prostate and testis).